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It is the prevalent opinion that vitamin G deficiency is intimately associated with the complex syndrome of symptoms included under the term pellagra. The complexity of the disease is so evident that some reluctance is justified in accepting the view that a single food deficiency may be responsible for such a varied series of clinical manifestations. In fact, some writers have suggested that what is called pellagra may be a mixture of diseases rather than an entity,1 for in a given patient pellagra may involve predominantly only one system, whether this is the skin, alimentary tract or nervous system, and little damage may be done to the other systems;2 on the other hand, all three systems may be affected. Again, the symptoms observed may be so atypical of the classic features of pellagra that they have received the name pellagra sine pellagra. At the present stage of knowledge
UNDERHILL FP. CLINICAL ASPECTS OF VITAMIN G DEFICIENCY. JAMA. 1932;99(2):120–124. doi:10.1001/jama.1932.27410540007010a
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