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The story of the discovery of insulin is too well known to need repetition. The ready availability of the hormone has permitted a radical change in the mode of treatment of diabetes and as a consequence insulin has assumed an important place in therapeutics. These circumstances have stimulated the efforts of organic chemists to learn more about its structure with the ultimate hope that man's need may be safeguarded through the ability to synthesize it. A significant step in advance was made by Abel in 1926 when he succeeded in crystallizing insulin. Subsequently it was shown that this crystalline material exhibits the maximum physiologic activity so far obtained in any preparation. Furthermore, neither the mode of preparation nor the origin of the crude material from which the crystals are made seem to alter the potency of the final product. Thus, it appears that the crystalline material possesses the characteristics of
CHEMISTRY OF INSULIN. JAMA. 1932;99(6):480. doi:10.1001/jama.1932.02740580048013
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