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August 13, 1932


Author Affiliations


From the Section on Neurologic Surgery and the Division of Medicine, the Mayo Clinic.

JAMA. 1932;99(7):529-534. doi:10.1001/jama.1932.02740590009003

Thrombo-angiitis obliterans is a peripheral vascular disease, characterized by thrombosis of the peripheral arteries and veins, resulting in intermittent claudication, localized pain, edema, ulceration and gangrene of digits, and in the later stages of the disease,1 in massive gangrene. Besides the process of thrombosis, vasomotor spasm of principal unoccluded and collateral arteries is found which aggravates the symptoms produced by the occlusion of arteries and veins, and which, if relieved, ameliorates the symptoms, preserves digits and extremities and aids materially in rehabilitating the patient. Patients with mild symptoms may not require special treatment, whereas those with moderately advanced symptoms may respond to medical care. However, since these attacks are prone to recur in the affected extremity with extension to the opposite extremity, methods of treatment with more permanent effects have been sought. Our experiences with sympathetic ganglionectomy and trunk resection in the treatment of Raynaud's disease due to vasomotor

Adson, A. W., and Brown, G. E.:  The Treatment of Raynaud's Disease by Resection of the Upper Thoracic and Lumbar Sympathetic Ganglia and Trunks ,  Surg., Gynec. & Obst. 48: 577 ( (May) ) 1929
 Physiologic Effects of Thoracic and of Lumbar Sympathetic Ganglionectomy or Section of the Trunk ,  Arch. Neurol. & Psychiat. 22: 323 ( (Aug.) ) 1929.
Brown, G. E.; Allen, E. V., and Mahorner, H. R.:  Thrombo-Angiitis Obliterans , Philadelphia, W. B. Saunders Company, 1928.
Barker, N. W.: Personal communication to the authors.
Adson, A. W.:  The Results of Sympathectomy in the Treatment of Peripheral Vascular Diseases ,  Hirschsprung's Disease and Cord Bladder , to be published.
Brown. G. E., and Adson, A. W.:  Calorimetric Studies of the Extremities Following Lumbar Sympathetic Ramisection and Ganglionectomy ,  Am. J. M. Sc. 170: 232 ( (Aug.) ) 1925.
Simpson, S. L.; Brown, G. E., and Adson, A. W.:  Raynaud's Disease: Evidence That It is a Type of Vasomotor Neurosis ,  Arch. Neurol. & Psychiat. 26: 687 ( (Oct.) ) 1931.
Adson, A. W.:  Surgical Relief of Raynaud's Disease and Other Vascular Disturbances by Sympathetic Ganglionectomy and Perivascular Neurectomy ,  Ann. Clin. Med. 5:161 ( (Aug.) ) 1926.
Adson, A. W., and Brown, G. E.:  Thoracic and Lumbar Sympathetic Ganglionectomy in Peripheral Vascular Diseases: Therapeutic Value ,  J. A. M. A. 94: 250 ( (Jan. 25) ) 1930.
Adson, A. W.; O'Leary, P. A., and Brown, G. E.:  Surgical Treatment of Vasospastic Types of Scleroderma by Resection of Sympathetic Ganglia and Trunks ,  Ann. Int. Med. 4: 555 ( (Dec.) ) 1930.
Brown, G. E.; O'Leary, P. A., and Adson, A. W.:  Diagnostic and Physiologic Studies in Certain Forms of Scleroderma ,  Ann. Int. Med. 4: 531 ( (Dec.) ) 1930.
Henderson, M. S., and Adson, A. W.:  Sympathetic Ganglionectomy and Trunk Resection in Arthritis: Indications and Results ,  J. Bone & Joint Surg. 14: 47 ( (Jan.) ) 1932.
Weber, F. P.:  Return of Pulsation in Thrombo-Angiitis Obliterans ,  Brit. M. J. 2: 52 ( (July 12) ) 1924.
Adson, A. W.:  Cervicothoracic Ganglionectomy, Trunk Resection and Ramisectomy by the Posterior Intrathoracic Approach ,  Am. J. Surg. 11:227 ( (Feb.) ) 1931.
Adson, A. W., and Brown, G. E.:  Treatment of Raynaud's Disease by Lumbar Ramisection and Ganglionectomy and Perivascular Sympathetic Neurectomy of the Common Iliacs ,  J. A. M. A. 84: 1908 ( (June 20) ) 1925
 Raynaud's Disease of the Upper Extremities: The Successful Treatment by Resection of the Sympathetic Cervicothoracic and Second Thoracic Ganglions and the Intervening Trunk , Adson J. A. M. A. 92: 444 ( (Feb. 9) ) 1929.