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Thrombo-angiitis obliterans is a peripheral vascular disease, characterized by thrombosis of the peripheral arteries and veins, resulting in intermittent claudication, localized pain, edema, ulceration and gangrene of digits, and in the later stages of the disease,1 in massive gangrene. Besides the process of thrombosis, vasomotor spasm of principal unoccluded and collateral arteries is found which aggravates the symptoms produced by the occlusion of arteries and veins, and which, if relieved, ameliorates the symptoms, preserves digits and extremities and aids materially in rehabilitating the patient. Patients with mild symptoms may not require special treatment, whereas those with moderately advanced symptoms may respond to medical care. However, since these attacks are prone to recur in the affected extremity with extension to the opposite extremity, methods of treatment with more permanent effects have been sought. Our experiences with sympathetic ganglionectomy and trunk resection in the treatment of Raynaud's disease due to vasomotor
ADSON AW, BROWN GE. THROMBO-ANGIITIS OBLITERANS: RESULTS OF SYMPATHECTOMY. JAMA. 1932;99(7):529–534. doi:10.1001/jama.1932.02740590009003
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