[Skip to Content]
[Skip to Content Landing]
Article
August 20, 1932

NEUROLOGIC FEATURES OF PERNICIOUS ANEMIA

Author Affiliations

NEW YORK

From the Medical Clinic of the Peter Bent Brigham Hospital, Boston.

JAMA. 1932;99(8):612-614. doi:10.1001/jama.1932.02740600004002
Abstract

Studies of pernicious anemia have shown the presence of a wide variety of associated lesions in the central nervous system. As early as 1880, Little1 described cephalalgia, vertigo, syncope, neuralgic pains and mental depression, along with other symptoms of pernicious anemia. The exhaustive work of Russel, Batten and Collier2 followed that of Lichtheim,3 Putnam4 and Dana5 in the early description of the spinal cord changes. Certain of the lesions described by the former authors have not received mention since. Barrett6 and, particularly, Woltman7 have called attention to the cerebral changes. Bastianelli,8 Putnam and Taylor9 and others have reported optic atrophy in association with penicious anemia. The sensory changes have been described by many authors, but the work of Hamilton and Nixon10 is an excellent review of the subject and, in addition, reports pathologic changes in the peripheral nerves. A recent

References
1.
Little, H. W.:  Progressive Pernicious Anemia, a Disease of the Vasomotor System ,  M. Rec. 17: 313, 1880.
2.
Russell, J. S. R.; Batten, F. E., and Collier, J.:  Subacute Combined Degeneration of the Spinal Cord ,  Brain 23:39, 1900.Crossref
3.
Lichtheim:  Zur Kenntniss der perniciösen Anämie ,  Verhandl. d. Cong. f. innere Med. 6:84, 1887.
4.
Putnam:  A Group of Cases of System Sclerosis of the Spinal Cord, Associated with Diffuse Collateral Degeneration Occurring in Enfeebled Persons Past Middle Life, and Especially in Women; Studied with Particular Reference to Etiology ,  J. Nerv. & Ment. Dis. 16, (February) , 1891.
5.
Dana, C. L.:  Subacute Combined Sclerosis of the Spinal Cora and Its Relation to Anemia and Toxemia ,  J. Nerv. & Ment. Dis. 26: 1, 1889
6.
February and April, 1891.
7.
Barrett, A. M.:  Mental Disorders and Cerebral Lesions Associated with Pernicious Anemia ,  Am. J. Insan. 69:1063, 1913.
8.
Woltman, H. W.:  Brain Changes Associated with Pernicious Anemia ,  Arch. Int. Med. 21:791 ( (June) ) 1918.
9.
Bastianelli, G.:  Le sclerosi combinati del midollo spinale nelle anemie perniciosi ,  Bull. de roy. Acad. de med. di Roma 22: 197-244, 1896-1897
10.
ref.  Neurol. Centralbl. 16:78, 1897.
11.
Putnam, J. J., and Taylor, E. W.:  Diffused Degeneration of Spinal Cord ,  J. Nerv. & Ment. Dis. 28:1-21, 1901.
12.
Hamilton, A. S., and Nixon, C. E.:  Sensory Changes in the Subacute Combined Degeneration of Pernicious Anemia ,  Arch. Neurol. & Psychiat. 6: 1 ( (July) ) 1921.
13.
Michaud, L.:  Les troubles nerveux dans l'Anémie de Biermer: anémie de Biermer et sclerose combinée ,  Schweiz. med. Wchnschr. 61: 827-829 ( (Aug. 29) ) 1931.
14.
Woltman, H. W.:  Nervous Symptoms in Pernicious Anemia ,  Am. J. M. Sc. 157:400 ( (March) ) 1919.
15.
Smithburn, K. C., and Zerfas, L. G.:  The Neural Symptoms and Signs in Pernicious Anemia ,  Arch. Neurol. & Psychiat. 25: 1100 ( (May) ) 1931.
16.
McCrae, Thomas:  Pernicious Anemia: The Statistics of a Series of Forty Cases ,  J. A. M. A. 28:148-150 ( (Jan. 18) ) 1902.
17.
McPhaedran, A.:  Observations on the Nature and Treatment of Pernicious Anemia ,  Lancet 1:148-150, 1902.
18.
Murphy, W. P.: Personal communication to the author.
×