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Studies of pernicious anemia have shown the presence of a wide variety of associated lesions in the central nervous system. As early as 1880, Little1 described cephalalgia, vertigo, syncope, neuralgic pains and mental depression, along with other symptoms of pernicious anemia. The exhaustive work of Russel, Batten and Collier2 followed that of Lichtheim,3 Putnam4 and Dana5 in the early description of the spinal cord changes. Certain of the lesions described by the former authors have not received mention since. Barrett6 and, particularly, Woltman7 have called attention to the cerebral changes. Bastianelli,8 Putnam and Taylor9 and others have reported optic atrophy in association with penicious anemia. The sensory changes have been described by many authors, but the work of Hamilton and Nixon10 is an excellent review of the subject and, in addition, reports pathologic changes in the peripheral nerves. A recent
YOUNG RH. NEUROLOGIC FEATURES OF PERNICIOUS ANEMIA. JAMA. 1932;99(8):612–614. doi:10.1001/jama.1932.02740600004002
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