[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
August 27, 1932

CIRRHOSIS OF THE LIVER CAUSED BY CARBON TETRACHLORIDE

Author Affiliations

New Haven, Conn.

From the Medical Service of the New Haven Hospital.

JAMA. 1932;99(9):728-729. doi:10.1001/jama.1932.27410610001008
Abstract

Carbon tetrachloride has a widespread use with apparently little attention accorded to its danger as a toxic agent. Out of this neglect has appeared a case of cirrhosis of the liver similar to the experimental cirrhosis produced in dogs by the same substance. Although there are numerous records of acute yellow atrophy caused by carbon tetrachloride, no instance of liver cirrhosis has been reported in the literature.

The poison was assimilated by the patient through inhalation while at work. Lamson1 has produced a similar effect by immersing dogs in a concentrated vapor of carbon tetrachloride repeatedly over a period of one month. Autopsy of the animals showed the liver lesion to be one of healing central necrosis with stellate areas of collapsed framework about the hepatic veins. The adjacent liver cells in a wide band contained fat droplets.

Bollman and Mann2 in their work on experimentally produced lesions

References
1.
Lamson, P. D., and others:  Bull. Johns Hopkins Hosp. 36:107 ( (Feb.) ) 1923.
2.
Bollman, J. L., and Mann, F. C.:  Ann. Int. Med. 5:699 ( (Dec.) ) 1931.Crossref
3.
MacMahon, H. E., and Weiss, Soma:  Am. J. Path. 5:623 ( (Nov.) ) 1929.
4.
Rosenthal, S. M., and Lillie, R. D.:  Am. J. Physiol. 97:131 ( (April) ) 1931.
×