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In 1919, Weed and McKibbon1 demonstrated that the intravenious injection of a hypotonic solution increased the intracranial pressure. In 1923 and 1924, Weed2 found that the intravenous injection of a hypotonic solution in animals caused a hydrosis of the central nervous system. The essential changes were a hydrosis of the cells in the choroid plexus, a collection of fluid in the perineural spaces, a dilatation of the perivascular channels that lead into the subarachnoid space and an increased intracranial pressure.
In 1928, Kubie3 demonstrated that if a hypotonic solution is injected into the blood stream of animals there is a marked increase in intracranial pressure and a striking hydration of the central nervous system. If, however, a needle is introduced into the subarachnoid space and the increased fluid is allowed to drain, there is no rise in intracranial pressure and no hydrosis of the central nervous system
RETAN GM. FORCED SPINAL DRAINAGE IN ITS RELATION TO INFECTIONS OF THE CENTRAL NERVOUS SYSTEM. JAMA. 1932;99(10):826–831. doi:10.1001/jama.1932.02740620036008
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