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Article
October 29, 1932

RAYNAUD'S DISEASE: A CLINICAL STUDY OF ONE HUNDRED AND FORTY-SEVEN CASES

Author Affiliations

ROCHESTER, MINN.

From the Division of Medicine, the Mayo Clinic.

JAMA. 1932;99(18):1472-1478. doi:10.1001/jama.1932.02740700012003
Abstract

The confusion in diagnosis which even a cursory survey of the literature on Raynaud's disease shows to exist seems to have a single basis: departure from the criteria stated by Raynaud.1 These criteria are: (1) intermittent attacks of changes of color of the acral parts; (2) symmetrical or bilateral involvement; (3) absence of clinical evidence of occlusive lesions of the peripheral arteries, and (4) gangrene or trophic changes, if present, limited in large degree to the skin. To these four criteria laid down by Raynaud we have added a fifth and a sixth: (5) the disease must have been present for a minimal period of two years, and (6) there must be no evidence of disease to which it could be secondary. These additional criteria we have found necessary to exclude the secondary type of vasomotor disturbance. Early in the course of organic disturbance, the vasomotor manifestations may be

References
1.
Raynaud, A. G. M.:  De l'asphyxie locale et de la gangrène symétrique des extrémités , Paris, Rignoux, 1862.
2.
Allen, E. V., and Brown, G. E.:  Raynaud's Disease: A Critical Review of Minimal Requisites for Diagnosis ,  Am. J. M. Sc. 183: 187-200 ( (Feb.) ) 1932.Crossref
3.
Simpson, S. L.; Brown, G. E., and Adson, A. W.:  Raynaud's Disease: Evidence That It Is a Type of Vasomotor Neurosis ,  Arch. Neurol. & Psychiat. 26: 687-718 ( (Oct.) ) 1931.
4.
Raynaud (footnote 1).
5.
Lewis, Thomas:  Experiments Relating to the Peripheral Mechanism Involved in Spasmodic Arrest of the Circulation in the Fingers, a Variety of Raynaud's Disease ,  Heart 15: 7-100 ( (Aug. 3) ) 1929.
6.
Simpson, Brown and Adson (footnote 3, first reference).
7.
Landis, E. M.:  Micro-Injection Studies of Capillary Blood Pressure in Raynaud's Disease ,  Heart 15: 247-255 ( (Dec. 12) ) 1930.
8.
Frequently scleroderma and arthritis afflict the same patient. In 32 cases the scleroderma was more advanced; in 19 cases arthritis was of paramount importance. Trophic changes are frequently associated with scleroderma.
9.
Allen, E. V., and Brown, G. E.:  Raynaud's Disease Affecting Men ,  Ann. Int. Med. 5: 1384-1386 ( (May) ) 1932.
10.
Adson, A. W., and Brown, G. E.:  The Treatment of Raynaud's Disease by Resection of the Upper Thoracic and Lumbar Sympathetic Ganglia and Trunks ,  Surg., Gynec. & Obst. 48: 577-603 ( (May) ) 1929.
11.
Hench, P. S., and Craig, W. McK.:  Sympathetic Ganglionectomy and Ramisectomy for Chronic Infectious Arthritis: Clinical Interpretation ,  South. M. J. 24: 636-645 ( (July) ) 1931.
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