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Cutaneous sensitization to cocaine and related substances is not an infrequent occurrence. However, no case of bronchial asthma due to such a substance has been described as far as I can determine. The following case has been observed:
J. F., a girl, aged 12 years, who had been under my care since January, 1931, on account of perennial asthma, had been completely relieved for the past fourteen months by treatment with pollen extract and by the elimination of some of the substances to which she was sensitive. Since she complained of frequent nose bleeding, she was referred to a rhinologist (Dr. F. B. MacMullen) for cauterization of the bleeding nasal area. July 1, 1932, the doctor touched the mucosa of the septum with a cocaine crystal for the purpose of anesthesia. Immediately the patient had a very severe paroxysm of asthma, the first one within fourteen months. August 10 the
Waldbott GL. ASTHMA DUE TO A LOCAL ANESTHETIC. JAMA. 1932;99(23):1942. doi:10.1001/jama.1932.27410750002012a
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