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December 24, 1932


Author Affiliations


JAMA. 1932;99(26):2176-2177. doi:10.1001/jama.1932.02740780028007

So far, there have been three epochs in the present understanding and evaluation of xanthomatosis: the early description by Hand,1 Schüller2 and Christian,3 its classification and pathologic interpretation by Rowland,4 and its treatment by the roentgen ray, as described by Sosman.5 The papers by Rowland and Sosman cover the subject in detail and contain a complete bibliography.

After thoroughly culling the literature, Sosman6 was able to find the reports of forty-five cases of xanthomatosis. He suggested that there are probably any number of cases unreported or masked under some other diagnosis. Six cases under his care had been successfully treated with x-rays. He found that five other authors had reported good results with roentgen treatment.

The following case is reported because of the limited number now on record in the literature and because of the eminently satisfactory results obtained by radiation therapy:

R. M.,

Hand, A.:  Defects of Membranous Bones, Exophthalmus and Polyuria in Childhood; Is It Dyspituitarism?  Am. J. M. Sc. 162: 509 ( (Oct.) ) 1921.Crossref
Schüller, Arthur:  Ueber eigenertige Schadeldefekte in Jugenalter ,  Fortschr. a. d. Geb. d. Röntgenstrahlen 23: 12, 1915-1916.
Christian, H. A.:  Defects in the Membranous Bones, Exophthalmus and Diabetes Insipidus: An Unusual Syndrome of Dyspituitarism ,  M. Clin. North America 3: 849 ( (Jan.) ) 1920.
Rowland, R. S.:  Xanthomatosis and the Reticulo-Endothelial System ,  Arch. Int. Med. 42: 611 ( (Nov.) ) 1928.Crossref
Sosman, M. C.:  Xanthomatosis (Schüller's Disease; Christian's Syndrome): Report of Three Cases Treated with Roentgen Rays ,  Am. J. Roentgenol. 23: 581 ( (June) ) 1930.
Sosman, M. C.:  Xanthomatosis (Schüller-Christian's Disease, Lipoid Hystiocytosis) ,  J. A. M. A. 98: 110 ( (Jan. 9) ) 1932.Crossref