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Agents that are thought to act locally on the linings of the accessory sinuses, and thus affect the properties of immunity to disease which are inherent in such tissues in a state of health, will be discussed after brief consideration of those anatomic and pathologic factors that influence the choice and applicability of various classes of remedies.
Normal mucous membrane in the accessory sinuses is thin and pale, moistened by the moving film of mucus which is carried by ciliated cells to the ostium of each cavity.1 This ciliated lining contains numerous goblet cells and the apertures of sinus glands lying in the loose submucosal connective tissue, which serves also as periosteum and contains a scanty network of slender blood vessels.2
Within the connective tissue are found a few round cells, and near the capillaries special staining methods will demonstrate an occasional histiocyte, or so-called "reticulo-endothelial" cell, capable
FENTON RA. LOCAL AGENTS THAT INCREASE TISSUE IMMUNITY IN SINUS MUCOSA. JAMA. 1932;99(27):2247–2250. doi:10.1001/jama.1932.02740790017005
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