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Article
January 3, 1948

THE BACTERIOSTATIC AND BACTERICIDAL ACTIONS OF SOME MERCURIAL COMPOUNDS ON HEMOLYTIC STREPTOCOCCI: In Vivo and in Vitro Studies

Author Affiliations

Philadelphia

From the Department of Bacteriology, University of Pennsylvania School of Medicine.

JAMA. 1948;136(1):37-41. doi:10.1001/jama.1948.72890180010008
Abstract

Mercurial compounds have been employed as disinfectants since the beginning of bacteriology. Indeed, for a long period mercurial compounds, such as bichloride of mercury, headed the list of chemicals which were thought to be effective in the killing of microorganisms. This perhaps may be attributed to the favorable publicity which Koch1 in 1881 gave to bichloride of mercury during his work with the organism causing anthrax. In substance he stated that, without special preparation of the objects to be disinfected, bichloride kills by a single application of a very dilute solution, and in a few minutes even the most resistant forms of the organisms are killed.

Geppert2 in 1889 first pointed out that false inferences were drawn that bacteria were killed by the action of bichloride of mercury when growth of the organisms was prevented by traces of the chemical in the culture medium. In support of his

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