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Article
February 28, 1948

THE HEMORRHAGIC TENDENCY IN CONGESTIVE SPLENOMEGALY (BANTI'S SYNDROME): Its Mechanism and Management

Author Affiliations

Philadelphia

From the Division of Hematology, Department of Medicine, Jefferson Medical College of Philadelphia and Jefferson Medical College Hospital.

JAMA. 1948;136(9):616-621. doi:10.1001/jama.1948.02890260024007
Abstract

This paper is an exposition of some concepts of the mechanism of the hemorrhagic disorder encountered in Banti's syndrome (congestive splenomegaly, portal hypertension), of means for the recognition of its manifestations and of methods found useful in the control or amelioration of the tendency to bleed. The discussion that follows rests on observations made on 22 patients for whom a diagnosis of Banti's syndrome seemed indicated and who had had bleeding in one form or another. In 9 of the patients evidence of cirrhosis was obtained clinically, at operation or at necropsy. From the histories, it was probable that splenomegaly had preceded the manifestations of cirrhosis. Hematemesis or melena was the form of bleeding in 17 patients. Epistaxis, hematuria, vaginal bleeding, purpura and hemothorax were some of the other forms. The incidence of hemorrhagic complications in patients with this syndrome is difficult to estimate. Except for a brief mention of

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