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Article
May 29, 1948

DISAPPEARANCE OF CARCINOMATOUS ULCERATION OF BLADDER FOLLOWING URETEROSIGMOIDOSTOMY: Report of Two Cases

JAMA. 1948;137(5):450-453. doi:10.1001/jama.1948.02890390028006
Abstract

It is my purpose to report the clinical disappearance of carcinomatous ulceration of the bladder following diversion of the urinary stream and to point out the possible biologic significance of this phenomenon in connection with the cause of certain tumors of the bladder. These observations are based on repeated cystoscopic studies confirmed by preoperative biopsy and by subsequent gross and microscopic examination of the excised bladder by competent pathologists.1

The obvious inference that these tumors were caused by a carcinogenic urinary ingredient is thought provoking and involves a consideration of the closely related subject of chemical carcinogenesis, which may be defined as "the production of malignant, transplantable, metastasizing new growths in laboratory animals or human beings by the action of cancerproducing chemicals introduced into the body, intentionally or inadvertently, by ingestion, inhalation, injection or cutaneous application" (Davis2).

Although having received but scant mention in other than special journals,

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Dr. J. P. Tollman. Professor of Clinical Pathology, and Dr. H. E. Eggers, Chairman, Department of Pathology and Bacteriology, University of Nebraska College of Medicine.
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Pearse, R., in discussion on Davis.2
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