[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
June 5, 1948

TREATMENT OF MULTIPLE MYELOMA WITH "STILBAMIDINE": Clinical Results and Morphologic Changes

JAMA. 1948;137(6):513-516. doi:10.1001/jama.1948.02890400017003
Abstract

Up to the present time 35 patients with multiple myeloma have been subjected to treatment with "stilbamidine" (4.4'—stilbenedicarboxamidine). In this article experiences which have been collected will be reviewed and morphologic changes in the cytoplasm of the myeloma cells which result from this treatment will be discussed.

CLINICAL RESULTS 

A. Dosage.—  "Stilbamidine" can be given intravenously. If no veins are accessible the drug can also be injected intramuscularly. After a first injection-of 50 mg. and a second injection of 100 mg., each subsequent injection should amount to 150 mg. A total of fifteen to twenty injections is usually sufficient to alleviate the pain. "Stilbamidine" should not be autoclaved or filtered before use. The crystal-like substance should be weighed out. For intravenous use it is dissolved in 10 cc. of sterile water; for intramuscular use in 5 cc. of a 2 per cent solution of procaine hydrocholoride. Intramuscular injections should be

References
1.
Arai, H., and Snapper, I.:  The Influence of Stilbamidine upon Kidney Function, Liver Function and Peripheral Blood in Multiple Myeloma: Neurological Sequelae of Stilbamidine Therapy ,  New York State J. Med. , to be published.
2.
Snapper, I.:  Influence of Stilbamidine and Pentamidine on the Course of Multiple Myeloma ,  J. A. M. A. 133: 157-161 ( (Jan. 18) ) 1947.Crossref
3.
Snapper, I.:  Influence of Stilbamidine on Multiple Myeloma ,  J. Mt. Sinai Hosp. 13:119-127, 1946.
4.
Snapper, I., and Schneid, B.:  The Influence of Stilbamidine on Myeloma Cells ,  Blood 1:534-536, 1946.
5.
Snapper, I., and Schneid, B.  The Development of Basophilic Inclusion Bodies in Myeloma Cells After Stilbamidine Treatment ,  Ann. Int. Med. , 27: 541-547 ( (Oct.) ) 1947.Crossref
6.
Snapper, I.; Mirsky, A. E.; Ris, H.; Schneid, B., and Rosenthal, M.,  Development of Inclusion Bodies Containing Ribosenucleic Acid in Myeloma Cells After Injection of Stilbamidine : Determination of Stilbamidine in Myeloma Tissue Blood , 2: 311-322 ( (July) ) 1947.
7.
Unpublished experiments.
×