[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
June 19, 1948


Author Affiliations

Montreal, Canada

From the Departments of Pediatrics and Neurology, McGill University, and from the Children's Memorial Hospital and Neurological Institute.

JAMA. 1948;137(8):690-697. doi:10.1001/jama.1948.02890420024006

There has been much speculation as to the extent of cerebral involvement in poliomyelitis. Recent pathologic and experimental material has suggested that it is greater than what would be suspected on clinical grounds.

The proportion of cases with frank clinical manifestations of encephalitis is relatively small in most epidemics of poliomyelitis. In those instances, the drowsiness deepening into coma, often profound and prolonged, the tremors and the rigidity, leave no doubt as to the invasion of the brain by the disease process. Involvement of the brain is much less certain in milder clinical pictures, although it has been suspected as an explanation of the unusual-emotional states often encountered during the acute stage of poliomyelitis. As for the disturbed behavior which has been known to occur as a late sequel of poliomyelitis, and which is being extensively studied,1 most explanations have been based on the psychologic trauma of crippling disabilities

Ebaugh, F. G., and Hoekstra, C. S.:  Psychosomatic Relationships in Acute Anterior Poliomyelitis ,  Am. J. M. Sc. 213:115-121 ( (Jan.) ) 1947.Crossref
Stanfield, C. E.:  Personality Repurcussions _of Anterior Poliomyelitis: A Review of the Literature ,  Am. J. M. Sc. 213: 109-114 ( (Jan.) ) 1947.Crossref
Crothers, B., and Meyer, E.:  The Psychologic and Psychiatric Implications of Poliomyelitis ,  J. Pediat. 28: 324-326 ( (March) ) 1946.Crossref
Myer, E.:  Psychological Considerations 'in a Group of Children with Poliomyelitis ,  J. Pediat. 31:34-38 ( (July) ) 1947.Crossref
Hurst, E. W.:  The Histology of.Experimental Poliomyelitis ,  J. Path. & Bact. 32:457-477 ( (July) ) 1929.
Sabin, A. B., and Ward, R.:  The Nature of Non-Paralytic and Transitory Paralytic Poliomyelitis in Rhesus Monkeys Inoculated with Human Virus ,  J. Exper. Med. 73:757-770 ( (June) ) 1941.
Bodian, D., and Howe, H. A.:  Experimental Non-Paralytic Poliomyelitis: Frequency and Range of Pathologic Involvement ,  Bull. Johns Hopkins Hosp. 76: 1-17 ( (Jan.) ) 1945.
Faber, H. K.:  Acute Poliomyelitis as a Primary Disease of the Central Nervous System: A Review ,  Medicine 12:83-136 ( (May) ) 1933.
Peers, J. H.:  The Pathology of Convalescent Poliomyelitis in Man  Am. J. Path. 19:673-695 ( (July) ) 1943.
Wiglesworth, F. W.: Personal communication to the author.
Dr. F. M. Worden granted us permission to examine the records of thepoliomyelitis wards at the Alexandra Hospital.
Jasper, H. H.;  Electrical Activity of the Brain ,in Luck, J. M.:  Annual Review of Physiology , Stanford University, Calif., Annual Reviews, Inc., 1941. vol. 3, pp. 377-398.
Jasper, H. H.: Kershman, J., and Elvidge, A.:  Electroencephalographic Studies of Injury to the Head ,  Arch. Neurol. & Psychiat. 44: 328-350 ( (Aug.) ) 1940.
Liberson, W. T., and Strauss, H.:  Electroencephalographic Studies: Slow Activity During Hyperventilation in Relation to Age ,  Proc. Soc. Exper. Biol. & Med. 48: 674-676 ( (Dec.) ) 1941.
Lindsley, D. B., and Cutts, K. K.:  Clinical and Electroencephalographic Changes in a Child During Recovery from Encephalitis ,  Arch. Neurol & Psycluat. 45:156-161 ( (Jan.) ) 1941.
Ross, J. S.:  Electroencephalographic Findings During and After Acute Encephalitis ,  J. Nerv. & Ment. Dis. 102: 172-182 ( (Aug.) ) 1945.