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Article
October 9, 1948

EFFECT OF PROCAINE ON THE HEART

Author Affiliations

Beverly Hills, Calif.

JAMA. 1948;138(6):449. doi:10.1001/jama.1948.02900060053023

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Abstract

To the Editor: —  The hazards attending the intravenous administration of procaine, recently advocated in the treatment of bronchial asthma and other conditions, have been pointed out by Waldbott in The Journal, April 26, 1947, and again in Queries and Minor Notes in the Aug. 21, 1948 issue.The hazards of this procedure are further indicated by our recent experimental electrocardiographic observations in the dog (Am. Heart Journal, in press). These studies revealed that intravenously administered procaine is capable of exerting a direct effect on the heart. The most striking result was a powerful depressant action on the conduction system, manifested by a tendency to prolongation of the P-R and QRS intervals, and leading to the development of auriculoventricular and intraventricular block. Other findings suggested some alteration in the invasion and retreat patterns of impulse spread, indicating an effect on the myocardium per se. The deleterious effects of the drug

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