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In March of this year (1948) Dr. Fernando Latapí of Mexico City demonstrated to one of us (H. L. A.) a case of actinomycosis in which an extensive cutaneous granuloma was healing rapidly, apparently as a result of the oral administration of disodium formaldehyde sulfoxylate diaminodiphenylsulfone ("diasone," Abbott). A similar response had been observed by him in two previously treated patients with this disease. The dose employed was that customarily used in the treatment of leprosy in Mexico: 15 grains (1 Gm.) daily for the first week, 20 grains (1.3 Gm.) daily for the second week and 25 grains (1.6 Gm.) daily thereafter. This is a much larger initial dose than that used in Hawaii (5 grains [0.3 Gm.] a day, three days a week, raised in 5 grain [0.3 Gm.] increments, on those days only, till 25 grains [1.3 Gm.] is reached, and then the same initial dose and
ARNOLD HL, AUSTIN ER. "DIASONE" THERAPY OF ACTINOMYCOSIS OF THE JAW: Report of a Case. JAMA. 1948;138(13):955–956. doi:10.1001/jama.1948.62900130001007
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