[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Other Articles
April 21, 1951

ARTERIOSCLEROSIS: RECENT ADVANCES IN THE DIETARY AND MEDICINAL TREATMENT

Author Affiliations

Los Angeles

From the Division of Medicine, Los Angeles County General Hospital, and the Department of Internal Medicine, College of Medical Evangelists.

JAMA. 1951;145(16):1232-1236. doi:10.1001/jama.1951.02920340010004
Abstract

Up to recently arteriosclerosis was regarded as an incurable state—the inevitable result of advancing age and the remorseless effect of wear and tear or "rusting out" of the arteries. Arteriosclerosis in its various forms ranks first as a cause of death and disease in the United States.

Accumulated evidence refutes these fatalistic resignations, stressing the concept that atherosclerosis is a metabolic error, in which disorders of the blood lipids and lipoproteins play a dominant role. The work of numerous investigators1 has shown that arteriosclerosis whose clinical aspects are better known as atherosclerosis2 is a reversible disease in the experimental animal3 and that it shows equally promising therapeutic responses in humans.4

Recent studies5 have indicated that an excess of ingested dietary fats, or persistent alimentary hyperlipemia, appears to be the factor responsible for atherosclerosis (although I believe that there are several factors). Numerous opponents have countered

References
1.
Steiner, A.:  Effect of Choline on Production of Experimental Atherosclerosis in Rabbits ,  Proc. Soc. Exper. Biol. & Med. 39: 411, 1938.
2.
 Cholesterol in Arteriosclerosis with Special Reference to Coronary Arteriosclerosis ,  Med. Clin. North America 34: 673, 1950.
3.
Hueper, W. C.:  Arteriosclerosis: A Review ,  Arch. Path. 38: 162-364 ( (Sept.) ) 1944; 39:51, (Jan.); 117 (Feb.); 187 (March).
4.
Morrison, L. M.:  The Prevention of Experimental Atherosclerosis by Choline Feeding ,  Geriatrics 4:236, 1949.
5.
Morrison, L. M., and Rossi, A.:  Absorption of Aortic Atherosclerosis by Choline Feeding ,  Proc. Soc. Exper. Biol. & Med. 69: 283, 1948.
6.
Herrman, G. R.:  Some Experimental Studies in Hypercholesterolemic States ,  Exper. Med. & Surg. 5: 149, 1947.
7.
Wolffe, J. B.:  Atheromatosis to be Distinguished from Arteriosclerosis ,  Mil. Surgeon 97:92, 1945.
8.
Broun, G. O.; Andrews, K. P., and Corcoran, P. J. V.:  Studies on the Effect of Lipotropic Agents in Experimental Cholesterol Atherosclerosis in the Rabbit ,  Geriatrics 4: 178, 1949.
9.
Morrison, L. M., and Gonzalez, W. F.:  Results of Treatment of Coronary Atherosclerosis with Choline .  Am. Heart J. 39:729, 1950.
10.
Morrison, L. M.:  Reduction of Mortality Rate in Coronary Atherosclerosis on a Low Cholesterol-Low Fat Diet ,  Am. Heart J. , to be published.
11.
Moreton, J. R.:  Atherosclerosis and Alimentary Hyperlipemia ,  Science 106:190, 1947
12.
 Chylomicronemia, Fat Tolerance and Atherosclerosis ,  J. Lab. & Clin. Med. 35:373, 1950.
13.
Gofman, W. J.; Lindgren, F.; Elliott, H.; Mantz, W.; Hewitt, J.; Strisower, B., and Herring, V.:  Role of Lipids and Lipoproteins in Atherosclerosis ,  Science 111:166, 1950.
14.
Necheles, H.; Meyer, J., and Becker, G. H.:  Fat Absorption in Young and Old Age ,  Gastroenterology 14: 80, 1950.
15.
Zinn, W. J., and Griffith, G. C.:  A Study of Serum Fat Globules in Atherosclerotic and Non-Atherosclerotic Male Subjects ,  Am. J. M. Sc. 220:597, 1950.
16.
Morrison, L. M.; Zwierlein, M., and Wolfson, E.:  Fat Tolerance in Coronary Atherosclerosis ,  Am. Heart J. 38: 455-480, 1949.
17.
Frazier, A. C., and Stewart, H. C.:  Chylomicrograph Technique ,  J. Physiol. 95:21P-23P, 1939.
18.
Katz, L.; Stamler, J., and Horlick, L.:  Cholesterol Metabolism in Health and Disease: Its Relationship to Arteriosclerosis ,  Am. Pract. 1:461, 1950.
19.
Kellner, A.; Correll, J. W., and Ladd, A. T.:  Modification of Experimental Atherosclerosis by Means of Intravenous Detergents ,  Am. Heart J. 38: 455-457, 1949.
20.
Morrison, L. M., and Johnson, K. D.:  The Cholesterol Content of the Coronary Arteries and Blood in Acute Coronary Thrombosis ,  Am. Heart J. 39:31, 1950.
21.
Morrison, L. M.; Hall, L., and Chaney, A. L.:  Blood Serum Cholesterol Levels in 200 Cases of Acute Coronary Thrombosis ,  Am. J. M. Sc. 216: 32, 1948.
22.
Morrison, L. M., and Gonzalez, W. F.:  The Effect of Blood Cholesterol Disorders on the Coronary Arteries and Aorta ,  Geriatrics 5: 188, 1950.
23.
Morrison, L. M.:  The Role of the Liver in Atherosclerosis ,  Ann. West Med. & Surg. 4: 665, 1950.
24.
Snapper, I.:  Chinese Lessons to Western Civilization , New York, Interscience Publishers, Inc., 1941.
25.
Dock, W.:  The Predilection of Atherosclerosis for the Coronary Arteries ,  J. A. M. A. 131:875 ( (July 13) ) 1946.
26.
Plotz, M.:  Combined Coronary Disease and Peptic Ulcer ,  Rev. Gastroenterol. 15:628, 1948.
27.
Steiner, P. E.:  Necropsies on Okinawans ,  Arch. Path. 42: 359 ( (Oct.) ) 1946.
28.
Adlersberg, D.; Parets, A. D., and Boas, E. D.:  Familial Hypercholesterolemia and Atherosclerosis ,  J. A. M. A. 141: 246 ( (Sept. 24) )1949.
29.
Wilkinson, C. F.; Blecha, E., and Reimer, A.:  Arch. Int. Med. 85:389 ( (March) ) 1950.
30.
Morrison, L. M.; Chaney, A. L., and Gonzalez, W. F.:  The Significance of Human Blood Serum Cholesterol Variations ,  J. Lab. & Clin. Med. 34: 1473, 1949.
31.
Ahrens, E. H., and Kunkel, H. G.:  Stabilization of Serum Lipid Emulsions by Serum Phospholipids ,  J. Exper. Med. 90: 409, 1949.
32.
Sobel, H., and Morrison, L. M.:  The Effect of Saponin on the Serum of Normal and Atherosclerotic Individuals ,  Circulation 2: 460-480, 1950.
33.
Deleted in proof.
34.
Leinwand, I., and Moore, D. H.:  Simultaneous Studies on the Serum Lipids and the Electrophoretic Pattern of the Serum Protein in Man ,  Am. Heart J. 38:455-480, 1949.
35.
Footnotes 4c and 11a.
36.
Korenchevsky, V.; Paris, S. K., and Benjamin, B.:  Treatment of Senescence in Female Rats with Sex and Thyroid Hormones ,  J. Gerontol. 5: 120, 1950.
37.
White, N. K.; Edwards, J. E., and Dry, T. J.:  The Relationship of the Degree of Coronary Atherosclerosis with Age, in Men ,  Circulation 1: (pt. (2) ) 645, 1950.
×