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THERE ARE OBVIOUS ADVANTAGES to the physician if he is able to prescribe certain drugs in preparations which in one dose contain a sufficient amount of medication to last all day or all night. Although enteric-coated tablets probably represent the first attempt to alter the release of drugs, a variety of drugs are available now in prolonged, sustained, delayed, repeat-action, and timed-release dosage forms. Enthusiastic advertisements for some of these products, which may be generally considered as having prolonged-action, purport to describe just when and how much of a drug is released, and simplified curves of blood levels or clinical response claim to depict how the preparation will act in vivo. Since these products usually contain the equivalent of 3 normal doses of the drug, it is of considerable importance to the physician to know that the drug will actually be released in the advertised manner and not released either
Campbell JA, Morrison AB. Oral Prolonged-Action Medication. JAMA. 1962;181(2):102–105. doi:10.1001/jama.1962.03050280032005b
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