[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
August 11, 1962

Carcinoid Tumors of the Rectum

Author Affiliations


JAMA. 1962;181(6):552-554. doi:10.1001/jama.1962.03050320090010

CARCINOID TUMORS of the rectum are uncommon, slow-growing, malignant submucosal lesions having full potentialities for local invasion and widespread metastatic dissemination. They were first described by Lubarsch in 1888 and named by Oberndorfer in 1907. Since that time they have been reported occurring in almost any tissue derived from primitive ectoderm as well as in teratomas. They are, however, most frequently encountered in the appendix. Occurrence within the rectum was first recorded by Saltykow in 1912. With the acceptance of proctosigmoidoscopy as an established procedure in the routine physical examination, the occurrence of this lesion in the rectum has been mentioned with increasing frequency.

These tumors are derived from the Kulschitzky (or argentaffin) cells located deep in the crypts of Lieberkühn. Initially these lesions, like simple adenomata, have no characteristic signs or symptoms. But upon examination, they are found to be small, rubbery, firm, discrete, freely movable, nonencapsulated, nodular thickenings

Lubarsch, O.:  Ueber den primaeren Krebs des Ileum Nebst Bemerkuengen uber das Gleichzeitige Vorkommen von Krebs und Tuberculose ,  Virchow Arch J Path Anat 111:280, 1888.
Oberndorfer, S.:  Uber die Kleinen Dunndarm Carcinome verhandl Deutsch Path ,  Gesellsen 11:113, 1909.
Warren, K. W., and Coyle, E. B.:  Carcinoid Tumors of Gastro-intestinal Tract ,  Amer J Surg 82:372, 1951.Crossref
Saltykow, S.:  Ueber die Genese der Karzinoiden Tumoren sowie dor "Adenomyome" des Darmes ,  Beitr Path Anat 54:559, 1912.
Masson, P.:  Carcinoids (Argentaffin-cell Tumors) and Nerve Hyperplasia of Appendicular Mucosa ,  Amer J Path 4:181, 1928.
Pearson, C., and Fitzgerald, P. J.:  Carcinoid Tumors: Reemphasis of their Malignant Nature ,  Cancer 2:1005, 1949.Crossref
McGregor, J. K., and McGregor, D. D.:  Adenocarcinoma of Appendix ,  Surgery 48:925, 1960.
Applebaum, H. S.:  Functioning Carcinoids with Case Report ,  Ohio Med J 56:62, 1960.
Tavenner, M. C.; Bacon, H. E.; and Peale, A. R.:  Carcinoid Tumors of Rectum ,  J Int Coll Surg 16:265, 1951.