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August 25, 1962

Clinical Science

JAMA. 1962;181(8):706-716. doi:10.1001/jama.1962.03050340044009

Autoantibodies and Autoimmune Diseases  Felix Milgrom, M.D., and Ernest Witebsky, M.D., BuffaloNO ATTEMPT has been made to completely review this most extensive topic. It was primarily intended to connect frequently neglected basic immunological concepts with studies on autoimmunization. For this purpose investigations were selected for discussion which seemed to illustrate well the problems involved. Admittedly, the investigations with which the authors are most familiar have been emphasized.The term "autoantibody" has been used in recent years throughout the medical literature with steadily increasing frequency. However, in spite of great interest in the topics covered by this term, the semantics involved is neither clearly defined nor uniform. It seems reasonable to begin this discussion with a few definitions.Stimulation of an animal with antigens originating from a foreign species is the best known and possibly the most frequently occurring immunological process. Naturally and artificially acquired immunity to microorganisms and their