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It is axiomatic that if we are to understand and effectively treat the pathologic entity of shock, we have need for information which identifies the mechanisms which participate critically in the course of the syndrome. As clinicians, we are familiar with shock. The circumstances leading to its development are well known as are the signs and symptoms and many of its overt and subtle cardiovascular manifestations. Considerable proficiency in the treatment of this disturbance has been developed. Yet, the pathogenesis of shock, in terms of its essential etiology and its prediliction to develop into a lethal entity in the face of all known therapy, has not been explained. Included in this issue are 4 contributions beginning on page 866 to the pathogenesis of shock. From the discussions it is evident that the phenomenon remains elusive in that the basic mechanisms leading to its irreversible disruptive consequences are yet to be
Hershey SG. MECHANISMS IN SHOCK. JAMA. 1962;181(10):894–895. doi:10.1001/jama.1962.03050360080017
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