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September 8, 1962

Acute Pancreatitis and Steroid Therapy

Author Affiliations

33 Barclay St., Canajoharie, N.Y.

JAMA. 1962;181(10):920. doi:10.1001/jama.1962.03050360106025

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To the Editor:—  The letters of Drs. Irvin S. Eskwith and Wil B. Nelp on "Acute Pancreatitis and Steroid Therapy" (JAMA179:916 [March 17] 1962) call for further discussion of the proper therapeutic administration of steroids. Having used them for more than a decade, I offer the following remarks.Steroids are either administered orally or hypodermically. When given by mouth, the problem of absorption enters the picture and is bound to complicate it. Dr. Nelp reports in his letter 3 cases which offer proof for the fact that it is impossible to predict how much of a drug will be absorbed from the intestinal tract.One patient received 840 mg. of prednisolone in 14 days, another had 510 mg. in 17 days, and the third, 280 mg. in 7 days. In these 3 cases symptoms of severe pancreatitis developed. It is obvious that each of these patients absorbed prednisolone to