[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
September 29, 1962

Partial Albinism: Nine Cases in Six Generations

Author Affiliations

Los Angeles
Resident in Dermatology (Doctor Campbell), Instructor in Dermatology (Doctor Swift), Pediatric Dermatology Clinic, Department of Dermatology, White Memorial Hospital and Clinic, Loma Linda University.

JAMA. 1962;181(13):1103-1106. doi:10.1001/jama.1962.03050390005002
Abstract

Partial albinism is a rare congenital defect of the skin, in which absence of melanin pigment in various areas is found at birth and is permanent. In contrast to total albinism, it is a genetic dominant, and never involves any organ except the skin. Six members of a Mexican family who have varying degrees of partial albinism have been seen. They all showed the most common feature of the condition, a depigmented strip of hair arising in the frontal area and known as a "white forelock," in addition to other patches of depigmentation. Histologic studies that employed special staining techniques were unable to demonstrate any melanin formation in the white spots. Therapeutic trial, using one of the oral psoralen derivatives, failed to stimulate melanogenesis.

References
1.
Smith, N. G., and Schulz, J.:  Partial Albinism ,  Arch Dermat 71:468, 1955.Crossref
2.
Morgan, J.:  Some Accounts of Motley Coloured or Pye Negro Girl and Mulatto Boy ,  Trans Amer Phil Soc 2:392, 1786.Crossref
3.
Simon, T.:  On Partial Albinism in Negroes and Europeans ,  Deutsche Klin 13:399, 1861.
4.
Berger, O.:  Two Cases of Premature Canities ,  Virchow Arch Path Anat 53:533, 1871.
5.
Rizzoli, F.:  Congenital White Forelock ,  Bol Soc Med Chir Bologna 23 (Ser. 5), 1877.
6.
Cromwell, A. M.:  Inheritance of White Forelock in Mulatto Family ,  J Hered 31:94, 1940.
7.
Cooke, J. V.:  Familial White Skin Spotting with White Forelock ,  J Pediat 41:1, 1952.Crossref
8.
Jahr, H. M., and McIntire, M. S.:  Piebaldness, or Familial White Skin Spotting ,  Amer J Dis Child 88:481, 1954.
9.
Huf; Fosnaugh; and Lesney, P. F.:  Studies on Albinism ,  Arch Derm 77:723, 1961.
10.
Ansari, M. Y.:  Partial Albinism ,  J Ind Med Assoc 34:49, 1960.
11.
Waardenburg, P. J.:  New Syndrome Combining Developmental Anomalies of Eyelids, Eyebrows, and Nose Root with Pigmentary Defects of Iris and Head Hair with Congenital Deafness ,  Amer J Hum Genet 3:195, 1951.
12.
Ito, M.:  Lentigo Achromiant in Albinos ,  Ann Dermat Syph 83:631, 1956.
13.
Bhenda, Y. M.:  Malignant Amelanotic Melanoma of the Skin in Albino ,  Indian J Med Sc 6:755, 1952.
14.
Young, T. E.:  Malignant Melanoma in Albino ,  Arch Path 64:186, 1958.
15.
Leonardi, R., and Grasso, S.:  Melanoblastoma in Albino: Histologic Findings ,  Minerva Dermat 33:24, 1958.
16.
Barnicot, N. A., and Birbeck, M. S. C.:  Electron Microscopy of Human Melanocytes and Melanin Granules , in: Montagna, W., and Ellis, R. A.:  Biology of Hair Growth , New York City: Academic Press, Inc., 1959.
17.
Becker, S. W., Jr.; Fitzpatrick, T. B.; and Montgomery, H.:  Human Melanogenesis: Cytology of Human Pigment Cells (Melanodendrocytes) ,  Arch Dermat Syph 65:511, 1952.Crossref
18.
Silvers, W. K.:  Histological and Experimental Approach to Determine Relationship Between Gold-Impregnated Dendritic Cells and Melanocytes ,  Amer J Anat 100: 225, 1957.Crossref
19.
Sanders, J.:  Two Families with Albinismus Circumscriptus ,  Genetica 17:185, 1935.Crossref
20.
Stanbury, J. B.; Wyngaarden, J. B.; and Fredrickson, D. S.:  Metabolic Basis of Inherited Disease , New York City: McGraw-Hill Book Co. Inc., 1960, pp. 52.
×