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September 29, 1962


JAMA. 1962;181(13):1130-1132. doi:10.1001/jama.1962.03050390032010

New biological and histochemical techniques are playing an increasingly important role in many research areas of laboratory and clinical medicine. Attempts to relate disorders of metabolism to various disease entities by means of isolated or correlated findings are fraught with dangers of misinterpretation. There is no doubt, however, that in our attempt to understand the pathophysiology of innumerable disease states, we may recognize a pattern evolving from a series of investigations which lends depth and new perspective to a previously confusing and complex array of isolated data. Hopefully, one day, the scattered pieces of the jig-saw puzzle will fit into their proper niche and permit a clearer understanding of the particular field and its clinical applications.

In an excellent editorial entitled "Ulcerative Colitis—A Challenge," published in the Archives of Internal Medicine in 1958, Kirsner discussed refreshingly the facts and questions of the over-all problem. He pointed out that the current

Calabresi, P.; Thayer, W. R., Jr.; and Spiro, H. M.:  Circulating Antinuclear Globulins in Ulcerative Colitis ,  J Clin Invest 40:2126-2133 ( (Dec.) ) 1961.Crossref
Calabresi, P.; Edwards, E. A.; and Schilling, R. F.:  Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders ,  J Clin Invest 38:2091, 1959.Crossref
Broberger, O., and Perlmann, P.:  Autoantibodies in Human Ulcerative Colitis ,  J Exp Med 110:657, 1959.Crossref
Polcak, J., and Vokurka, V.:  Auto-Immune Reactions in Course of Ulcerative Colitis ,  Amer J Dig Dis 5:395, 1960.Crossref
Bregman, E., and Kirsner, J. B.:  Colon Antibodies in Ulcerative Colitis , abstract,  J Lab Clin Med 56:795, 1960.
Lagercrantz, R.; Winberg, J.; and Zetterström, R.:  Extra-Colonic Manifestations in Chronic Ulcerative Colitis ,  Acta Paediat (Stockh) 47:675, 1958.Crossref
Pollak, V. E.; Mandema, E.; and Kark, R. M.:  Antinuclear Factors in Serum of Relatives of Patients with Systemic Lupus Erythematosus ,  Lancet 2:1061, 1960.Crossref