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New biological and histochemical techniques are playing an increasingly important role in many research areas of laboratory and clinical medicine. Attempts to relate disorders of metabolism to various disease entities by means of isolated or correlated findings are fraught with dangers of misinterpretation. There is no doubt, however, that in our attempt to understand the pathophysiology of innumerable disease states, we may recognize a pattern evolving from a series of investigations which lends depth and new perspective to a previously confusing and complex array of isolated data. Hopefully, one day, the scattered pieces of the jig-saw puzzle will fit into their proper niche and permit a clearer understanding of the particular field and its clinical applications.
In an excellent editorial entitled "Ulcerative Colitis—A Challenge," published in the Archives of Internal Medicine in 1958, Kirsner discussed refreshingly the facts and questions of the over-all problem. He pointed out that the current
CIRCULATING ANTINUCLEAR GLOBULINS. JAMA. 1962;181(13):1130–1132. doi:10.1001/jama.1962.03050390032010
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