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October 6, 1962

Negative Results

JAMA. 1962;182(1):67. doi:10.1001/jama.1962.03050400069012

Mebutamate as an Antihypertensive Agent  J. Marion Bryant, M.D., New York CityMEBUTAMATE (Capla), an analog of meprobamate (Miltown, Equanil) with an additional methyl group on the propyl side chain, has been reported to have antihypertensive properties.1-5 Blood pressure observations during mebutamate administration, with and without hydrochlorothiazide (Esidrix, Hydro Diuril), in a group of ambulatory subjects with long-standing essential hypertension are presented in this paper.

Material and Methods  Thirty-three patients (9 male and 24 female), 38 to 72 years of age (mean 59 ± 9), with hypertension of 1 to 26 years duration ( mean 9 ±7 ) were studied.Four control, nonrested, blood-pressure observations, in both recumbent and standing positions, were recorded. The means of these values are used in this report. Those designated "original" control were obtained at the first clinic visit, the "final" control at the end of placebo periods of 4 to 60 weeks (mean 16 ± 12),

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