[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
October 6, 1962

Skin Test Developed to Test Allergy to Penicillin

JAMA. 1962;182(1):A37-A38. doi:10.1001/jama.1962.03050400117049

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


A patient's allergy to penicillin may soon be determined by a simple skin test, according to researchers at the International Congress of Dermatology. Two viewpoints were presented on a skin test substance known as penicilloyl-polylysine, which creates a reaction in some individuals with immediate-type allergies to penicillin without sensitizing normal individuals.

Dr. W. G. Simpson of Washington, D.C., a U.S. Public Health Service epidemiologist, said that test results with the reagent are significant enough "to warrant optimism on the eventual usefulness of this test in determining penicillin sensitivity."

However, Simpson said, "a more comprehensive evaluation" is necessary before it is used generally by physicians.

Another report in the form of a scientific exhibit, was more enthusiastic.

Dr. A. L. de Weck and Dr. H. Kuske, from the Department of Dermatology, University of Bern, Switzerland, reported on experiences with penicilloyl-polylysine, administered as an injection or as a scratch test on 2,000