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April 17, 1967


JAMA. 1967;200(3):33-46. doi:10.1001/jama.1967.03120160011003

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Long-Term Contraception Near?  A "second generation" of contraceptive drugs, emphasizing long-term antifertility, is appearing on the clinical horizon.Planned Parenthood Physicians, meeting in Atlanta, were told:

  • Implantable, sustained release preparations, which could provide contraception for a year, may be ready for early clinical trial within six months.

  • Two injectable contraceptives so far have proven safe and acceptable in clinical trials ranging up to three years; but further study is required before general clinical use.

Discussing the possibility of implantable contraceptives, investigators from the Population Council, New York City, noted that the efficacy of daily, minute oral doses of progestogen—less than a milligram—has been proved extensively. Several field trials of this contraceptive approach have been conducted, including that in Mexico City by Jorge Martinez-Manatou, MD.Animal studies now indicate that the so-called mini-dose also can be dispensed through an implanted silastic capsule, injected microspheres, or similar techniques. "We need