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February 17, 1962

Acute Myelomonocytic Leukemia After Radioiodine Therapy of Hyperthyroidism

Author Affiliations

Galveston, Tex.

JAMA. 1962;179(7):572-573. doi:10.1001/jama.1962.03050070077019b

THE COMPLICATIONS of radioactive iodine therapy of hyperthyroidism are few. A theoretically possible complication is the occurrence of radiation-induced leukemia. This has probably followed x-ray therapy of ankylosing spondylitis and after the high-dosage radioactive iodine therapy of thyroid cancer. In an attempt to answer the question whether the lower dosage of radioactive iodine that is used in treatment of hyperthyroidism may be incriminated in leukemogenesis, Pochin analyzed data from 60,000 patients and found 18 cases of leukemia occurring during the 222,000 patient years of follow-up. This figure compared with an estimated expected incidence of 21 cases that might have occurred by chance. Because the number of cases in both the "observed" and "expected" series is small, it would be desirable to extend such observations to a larger number of patients. If such a relationship does exist, it is obviously important to define as early as possible the magnitude of the

Pochin, E. E.:  Leukaemia Following Radioiodine Treatment of Thyrotoxicosis ,  Brit Med J 2:1545-1550 ( (Nov. 26) ) 1960.Crossref
Werner, S. C.; Gittlesohn, A. M.; and Brill, A. B.:  Leukemia Following Radioiodine Therapy of Hyperthyroidism ,  JAMA 177:646-648 ( (Sept. 2) ) 1961.Crossref
Green, M., et al.:  Blood Radiation Dose After 1-131 Therapy of Thyrotoxicosis ,  Brit Med J 2:210-215 ( (July 22) ) 1961.Crossref
Court Brown, W. M., and Doll, R.:  Leukaemia and Aplastic Anaemia in Patients Irradiated for Ankylosing Spondylitis ,  Spec Rep Ser Med Res Council (London) , No. (295) , 1951.