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In the 12-year period of this study there has been marked improvement in the clinical picture of cervical carcinoma. An increasing number of carcinoma cases has been detected in the early stages, and, concurrently, the number of cases discovered in the advanced stages has been decreasing. These beneficial changes are principally the result of more widespread use of better detection methods, chiefly that of the routine Papanicolaou vaginal smear. There has also been an improvement in the 5-year survival rates following treatment with irradiation therapy; this has especially been true in the additional group of cases which received full irradiation followed by radical Wertheim hysterectomy with extraperitoneal pelvic lymphadenectomy. The better survival rate is the joint result of earlier detection of the disease and improvements in the treatment methods employed.
Stevenson CS, Brines OA, Harmison CR, Anderson KJ. Changing Picture of Cervical Carcinoma. JAMA. 1962;179(12):930–934. doi:10.1001/jama.1962.03050120008002
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