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March 24, 1962

Changing Picture of Cervical Carcinoma

Author Affiliations


From the Department of Obstetrics and Gynecology, Wayne State University College of Medicine, and the Gynecology Department, Detroit Receiving Hospital.; Karen J. Anderson is currently a premedical sophomore at Michigan State University.

JAMA. 1962;179(12):930-934. doi:10.1001/jama.1962.03050120008002

In the 12-year period of this study there has been marked improvement in the clinical picture of cervical carcinoma. An increasing number of carcinoma cases has been detected in the early stages, and, concurrently, the number of cases discovered in the advanced stages has been decreasing. These beneficial changes are principally the result of more widespread use of better detection methods, chiefly that of the routine Papanicolaou vaginal smear. There has also been an improvement in the 5-year survival rates following treatment with irradiation therapy; this has especially been true in the additional group of cases which received full irradiation followed by radical Wertheim hysterectomy with extraperitoneal pelvic lymphadenectomy. The better survival rate is the joint result of earlier detection of the disease and improvements in the treatment methods employed.

The project included cases at the Yates Clinic, the Prenatal Clinic at Herman Kiefer Hospital, and some other smaller blocks of cases, in addition to those at Receiving Hospital.
Kaiser, R. F., et al.:  Initial Effect of Community-Wide Cytologic Screening on Clinical Stage of Cervical Cancer Detected in Entire Community ,  J Nat Cancer Inst 25:863, 1960.
Stevenson, C. S., and Scipiades, E.:  Non-Invasive Potential "Carcinoma" of Cervix ,  Surg Gynec Obstet 66:822, 1938.
Younge, P. A.; Hertig, A. T.; and Armstrong, D.:  Study of 135 Cases of Carcinoma in Situ of Cervix at Free Hospital for Women ,  Amer J Obstet Gynec 58:867, 1949.
Erickson, C. C.:  Preliminary Report of 20,000 Women Studied by Vaginal Smear Technique in General Population Cancer Screening Project , (abstr.)  Proc Amer Ass Cancer Res 1:14, 1953.
Stevenson, C. S.:  Treatment of Carcinoma of Cervix with Full Irradiation Therapy Followed by Radical Pelvic Surgery ,  Amer J Obstet Gynec 75:888, 1958.
Stevenson, C. S.:  Combined Treatment of Carcinoma of Cervix with Full Irradiation Followed by Radical Pelvic Operation ,  Amer J Obstet Gynec 81:156, 1961.