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March 24, 1962

Busulfan in Pregnancy

Author Affiliations

Fort Lauderdale, Fla.

JAMA. 1962;179(12):973-974. doi:10.1001/jama.1962.03050120000013e

THE TREATMENT of chronic granulocytic leukemia with busulfan (Myleran) (1,4-dimethanesulfonoxybutane ) in pregnancy is, apparently, uncommon. In reviewing the literature, only 2 reported cases were found in which busulfan alone had been used during pregnancy. This case is being reported to further substantiate the findings of Ixumi and Sherman that busulfan given during pregnancy has no apparent effect upon the fetus.

Report of a Case

A 29-year-old white female, when first seen in October, 1956, had had a history of known chronic granulocytic leukemia since lanuary, 1956, and had been given x-ray therapy. At this time, the spleen was down to the umbilicus and quite tender, and the white-blood-cell count was 232,000. Following a total of 150 r of whole-body irradiation, the spleen had become less tender and had regressed considerably in size. Concurrently, the white-blood-cell count gradually fell to about 75,000 and then started increasing. In August, 1956, she

Izumi, H. M.:  Myleran in Pregnancy: Report of Case ,  JAMA 161:969( (July 7) ) 1956.Crossref
Sherman, J. L., and Locke, R. V.:  Case of Busulfan in Myelogenous Leukemia During Pregnancy ,  New Engl J Med 259:288-289 ( (Aug. 7) ) 1958.Crossref
Sokol, J. E., and Lessman, E. M.:  Effects of Cancer Therapeutic Agents on Human Fetus ,  JAMA 172:1765-1771 ( (April 16) ) 1960.Crossref
Diamond, I.; Anderson, M. M.; and McCreadie, S. R.:  Transplacental Transmission of Busulfan (Myleran) in Mother with Leukemia ,  Pediatrics (no. (1) ) 25:85-90 (Jan.) 1960.