[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
June 12, 1967

Intra-arterial Chemotherapy for Recurrent Neoplasms

Author Affiliations

From the Department of Surgery, Albert Einstein College of Medicine, Bronx, NY.

JAMA. 1967;200(11):913-917. doi:10.1001/jama.1967.03120240041006

Twenty-eight intra-arterial infusions were carried out in 25 symptomatic patients all of whom had recurrent but still regionally confined disease. Most patients had had previous surgery and/or radiation. Four of these patients died as a direct result of the treatment and ten others had complications. Four patients are still alive but have recurrences. The average survival time of the dead patients was 4 1/2 months after treatment. Although this type of treatment was occasionally helpful, few of our patients actually benefited significantly from it. Furthermore, the substantial complication rate and mortality limits its use as a palliative measure.

Seldinger, S.I.:  Catheter Replacement of the Needle in Percutaneous Arteriography ,  Acta Radiol 39:368-376 ( (May) ) 1953.Crossref
Tindel, S.:  Auricular Flutter Occurring During Intra-Arterial Methotrexate Infusion ,  Vasc Dis 2:135-139 ( (May) ) 1965.
Klopp, E.T., et al:  Fractionated Intra-Arterial Cancer: Chemotherapy With Methyl Bis Amine Hydrochloride: Preliminary Report ,  Ann Surg 132:811-832 ( (Oct) ) 1950.Crossref
Bierman, H.R., et al:  Effects of Intra-Arterial Administration of Nitrogen Mustard , abstracted,  Amer J Med 8:535 ( (April) ) 1950.Crossref
Sullivan, R.D.; Miller, E.; and Sikes, M.P.:  Antimetabolite-Metabolite Combination Cancer Chemotherapy: Effects of Intra-Arterial Methotrexate Intramuscular Citrovorum Factor Therapy in Human Cancer ,  Cancer 12:1248-1262 ( (Nov) -Dec) 1959.Crossref
Tarr, N., et al:  Intra-Arterial Infusion of Malignancies with 5-fluorouracil ,  Cancer Chemother Rep 14:23-37 ( (Oct) ) 1961.
Benson, J.W.; Kiehn, C.L.; and Holden, W.D.:  Cancer Chemotherapy by Arterial Infusion ,  Arch Surg 87:125-144 ( (July) ) 1963.Crossref
Nahum, A.M., and Rochlin, D.B.:  Regional Arterial Chemotherapy of Cancer of the Head and Neck ,  Surg Gynec Obstet , 115: 478-483 ( (Oct) ) 1962.
Watkins, E., Jr., and Sullivan, R.D.:  Cancer Chemotherapy by Prolonged Arterial Infusion ,  Surg Gynec Obstet 118:3-19 ( (Jan) ) 1964.
Baker, R.B., and Gaertner, R.A.:  Regional Arterial Infusion of Antimetabolites ,  J Surg Res 5:132-136 ( (March) ) 1965.Crossref
Helman, P., et al:  Intra-arterial Cytotoxic Therapy and X-ray Therapy for Cancer of the Head and Neck ,  Lancet 1:128130 ( (Jan 16) ) 1965.
Espiner, H.J., et al:  Cancer Chemotherapy by Intra-arterial Infusion ,  Lancet 1:177-181 ( (Jan 27) ) 1962.Crossref