[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
November 3, 1962

Infantile Spasms, Hypsarhythmia, and Mental Retardation: Response to Corticotropin and Its Relation to Age and Etiology in 21 Patients

Author Affiliations

Rochester, Minn.
From the Section of Pediatrics, Consultant in Pediatric Neurology (Dr. Millichap) and the Section of Physiology (Electroencephalography), Consultant in Neurophysiology (Dr. Bickford), Mayo Clinic and Mayo Foundation.

JAMA. 1962;182(5):523-527. doi:10.1001/jama.1962.03050440015004
Abstract

Twenty-one patients with infantile spasms and hypsarhythmia were treated with corticotropin (ACTH) or cortisone or both. The frequency of seizures was reduced in 11, and the electroencephalogram became normal or was improved in 8 of 18 patients who had recordings made before and after therapy. A beneficial response was obtained in 6 of 11 patients with seizures of undetermined etiology and in 5 of 10 patients with a history of anoxia or encephalitis. The response was better in the younger children; 8 of 10 infants less than 1 year of age and 2 of 9 children 1 year of age or older were benefited. Seizures were controlled in 5 to 7 patients whose intelligence quotients were 70 or more before treatment and in 6 of 14 patients who were mentally retarded.

References
1.
Gibbs, E. L.; Fleming, M. M.; and Gibbs, F. A.:  Diagnosis and Prognosis of Hypsarhythmia and Infantile Spasms ,  Pediatrics 13:66-72 ( (Jan.) ) 1954.
2.
Druckman, R., and Chao, D.:  Massive Spasms in Infancy and Childhood ,  Epilepsia (Amst) 4:61, 1955.Crossref
3.
Sorel, L., and Dusaucy-Bauloye, A.:  A propos de 21 cas d'hypsarythmia de Gibbs: Traitement spectaculaire par l'A.C.T.H. ,  Rev Neurol (Par) 99:136-138, 1958.
4.
Stamps, F. W., et al.:  Experience with ACTH Treatment of Hypsarhythmia , in Gibbs, F. A.:  Molecules and Mental Health , Philadelphia: J. B. Lippincott Company, 1959, pp. 121-123.
5.
Low, N. L.:  Infantile Spasms With Mental Retardation: II. Treatment With Cortisone and Adrenocorticotropin ,  Pediatrics 22:1165-1169 ( (Dec.) ) 1958.
6.
Dumermuth, G.:  Über die Blitz-Nick-Salaam-Krämpfe und ihre Behandlung mit ACTH und Hydrocortison ,  Helv Paediat Acta 14:250-270 ( (Sept.) ) 1959.
7.
Stamps, F. W., et al.:  Treatment of Hypsarhythmia with ACTH ,  JAMA 171:408-411 ( (Sept. 26) ) 1959.Crossref
8.
Bower, B. D., and Jeavons, P. M.:  Prognosis of Infantile Spasms ,  Arch Dis Child 34:357 ( (Aug.) ) 1959.
9.
Millichap, J. G.; Bickford, R. G.; and Backus, R. E.:  Infantile Spasms, Hyparhythmia and Mental Retardation: I. Study of Etiologic Factors in 61 Patients ,  Epilepsia 3:188-197 ( (June) ) 1962.Crossref
10.
Low, N. L., et al.:  Infantile Spasms With Mental Retardation: I. Clinical Observations and Dietary Experiments ,  Pediatrics 22:1153-1163 ( (Dec.) ) 1958.
11.
Cochrane, W. A.: Syndrome of Infantile Spasms and Progressive Mental Deterioration Related to Aminoacid and Pyridoxine Metabolism, Proceedings of IXth International Congress of Pediatrics, Montreal, 1959.
12.
Bower, B. D.:  Tryptophan Load Test in Syndrome of Infantile Spasms with Oligophrenia ,  Proc Roy Soc Med 54:540-544 ( (July) ) 1961.
13.
 Sections of Neurology and Section of Physiology, Mayo Clinic and Mayo Foundation, Rochester, Minn., Electroencephalography , in:  Clinical Examinations in Neurology , Philadelphia: W. B. Saunders Company, 1956, pp. 272-286.
14.
Jeavons, P. M., and Bower, B. D.:  Natural History of Infantile Spasms ,  Arch Dis Child 36:17-22 ( (Feb.) ) 1961.Crossref
15.
Bower, B. D., and Jeavons, P. M.:  Effect of Corticotropin and Prednisolone on Infantile Spasms with Mental Retardation ,  Arch Dis Child 36:23-33 ( (Feb.) ) 1961.Crossref
16.
Kellaway, P.:  Neurologic Status of Patients with Hypsarythmia , in Gibbs, F. A.:  Molecules and Health Mental , Philadelphia: J. B. Lippincott Company, 1959, pp. 134-149.
×