[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
July 3, 1967

Brain Tumor Chemotherapy With Methotrexate Given Intrathecally: A New Technique

Author Affiliations

From the Department of Surgery, Division of Neurosurgery, University of Kentucky School of Medicine, Lexington.

JAMA. 1967;201(1):15-17. doi:10.1001/jama.1967.03130010041009
Abstract

A new technique has been described for the intrathecal administration of cytotoxic agents with use of the components of a ventriculoatrial shunt. The results obtained in six patients given methotrexate intrathecally for a variety of intracranial tumors justifies further clinical trial.

References
1.
Wilson, C.B.:  Chemotherapy of Brain Tumors by Continuous Arterial Infusion ,  Surgery 55:640-653 ( (May) ) 1964.
2.
Norrell, H.A., and Wilson, C.B.:  Chemotherapy of Experimental Brain Tumors by Arterial Infusion ,  Surg Forum 16:429-431, 1965.
3.
Hockey, A.A., and Mealey, J., Jr.:  Effects of Intracisternal Vinblastine in Dogs ,  Surg Forum 16:427-429, 1965.
4.
Hyman, C.B., et al:  Central Nervous System Involvement by Leukemia in Children: II. Therapy With Intrathecal Methotrexate ,  Blood 25:13-22 ( (Jan) ) 1965.
5.
Ommaya, A.K.:  Subcutaneous Reservoir and Pump for Sterile Access to Ventricular Cerebrospinal Fluid ,  Lancet 2:983-984 ( (Nov 9) ) 1963.Crossref
6.
Rubin, R.C., et al:  Cerebrospinal Fluid Perfusion for Central Nervous System Neoplasms ,  Neurology 16:680-692 ( (July) ) 1966.Crossref
×