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A new technique has been described for the intrathecal administration of cytotoxic agents with use of the components of a ventriculoatrial shunt. The results obtained in six patients given methotrexate intrathecally for a variety of intracranial tumors justifies further clinical trial.
Norrell H, Wilson C. Brain Tumor Chemotherapy With Methotrexate Given Intrathecally: A New Technique. JAMA. 1967;201(1):15–17. doi:10.1001/jama.1967.03130010041009
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