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Article
July 10, 1967

CARDIAC ARRHYTHMIAS AND SODIUM DIPHENYLHYDANTOIN-AN APPRAISAL

JAMA. 1967;201(2):128-129. doi:10.1001/jama.1967.03130020074020
Abstract

Establishment of specific indications for new drugs not infrequently occurs in distinct stages. Initial enthusiasm may be prompted by preliminary reports which indicate that a new agent offers unique pharmacologic advantages. These euphoric estimates are soon tempered by descriptions of untoward or ineffectual responses. Finally, after observations upon larger series of patients are obtained, unhurried reflection permits a balanced estimate of the precise role which the drug fulfills. These phases of clinical acceptance may be clearly identified in the responses in the past decade to the antiarrhythmic agent, diphenylhydantoin (Dilantin).

Certain effects of diphenylhydantoin upon the heart were documented as early as 1938, four years after the introduction of this drug for the treatment of epilepsy. In 1958, Leonard described the successful clinical application of diphenylhydantoin in the treatment of ventricular tachycardia.1 Numerous publications since that time have described the effectiveness of this drug in the treatment of a

References
1.
Leonard, W.A.:  Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia ,  Arch Intern Med 101:714-717 ( (April) ) 1958.Crossref
2.
Unger, A.H., and Sklaroff, H.J.:  Fatalities Following Intravenous Use of Sodium Diphenylhydantoin for Cardiac Arrhythmias ,  JAMA 200: 335-336 ( (April 24) ) 1967.Crossref
3.
Gellerman, G.L., and Martinez, C.:  Fatal Ventricular Fibrillation Following Intravenous Sodium Diphenylhydantoin Therapy ,  JAMA 200: 337-338 ( (April 24) ) 1967.Crossref
4.
Conn, R.D.; Kennedy, J.W.; and Blackmon, J.R.:  The Hemodynamic Effects of Diphenylhydantoin ,  Amer Heart J 73:500-505 ( (April) ) 1967.Crossref
5.
Bigger, J.T., Jr.; Steiner, C; and Burris, J.O.:  The Effects of Diphenylhydantoin on Atrioventricular Conduction in Man ,  Clin Res 15: 196 ( (April) ) 1967.
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