[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
July 17, 1967

Control of Heparin Therapy With Activated Partial Thromboplastin Times

Author Affiliations

From the George Washington University Medical Division, the District of Columbia General Hospital, Washington.

JAMA. 1967;201(3):157-159. doi:10.1001/jama.1967.03130030027006
Abstract

In vitro and in vivo studies were carried out to determine whether a standardized laboratory procedure, the activated (kaolin) partial thromboplastin time (PTT), could be used to regulate heparin therapy. In vitro, increasing heparin concentrations caused progressive prolongation of both the Lee-White (L-W) coagulation time and the activated PTT. Comparison of the activated PTT with the L-W coagulation time in 78 patients revealed an approximate linear correlation between the two tests, with corresponding prolonged values for each test found in almost all heparinized patients. Our observations suggest that the activated PTT test procedure can be used to regulate heparin anticoagulation. The major advantage of this test is that it can be performed in the laboratory by trained technicians and completed within a few minutes.

References
1.
Hougie, C.:  Letter to the Editor: The Lee and White Test for Coagulation Time ,  Amer J Clin Path 36:537-538 ( (Dec) ) 1961.
2.
Perkins, H.A.; Rolfs, M.R.; and Torg, B.:  Assay of Blood Coagulation Factors in Heparinized Blood ,  Thromb Diath Haemorrh 11:254-266 ( (April) ) 1964.
3.
Hattersly, P.G.:  Activated Coagulation Time of Whole Blood ,  JAMA 196:436-440 ( (May 2) ) 1966.Crossref
4.
Belko, J.S., and Warren, F.:  The Recalcification Time of Blood ,  Arch Surg 76:210-218 ( (Feb) ) 1958.Crossref
5.
Rapaport, S.I., and Ames, S.B.:  Clotting Factor Assays on Plasma From Patients Receiving Intramuscular or Subcutaneous Heparin ,  Amer J Med Sci 234:678-685 ( (Dec) ) 1957.Crossref
6.
Struver, G.P., and Bittner, D.L.:  The Partial Thromboplastin Time (Cephalin Time) in Anticoagulant Therapy ,  Amer J Clin Path 38:473-481 ( (Nov) ) 1962.
7.
Struver, G.P.; Bittner, D.L.; and Wall, C.A.:  The Use of the Cephalin Time (Partial Thromboplastin Time) in Anticoagulation Therapy With Heparin ,  Surg Forum 13:127-129, 1962.
8.
Lenahan, V.G.; Frye, S.; and Phillips, G.E.:  Use of the Activated Partial Thromboplastin Time in the Control of Heparin Administration ,  Clin Chem 12:263-268 ( (May) ) 1966.
9.
Cartwright, G.E.:  Diagnostic Laboratory Hematology , ed 3, New York: Grune & Stratton, Inc., 1963, pp 152-154.
10.
Proctor, R.R., Rapaport, S.I.:  The Partial Thromboplastin Time With Kaolin ,  Amer J Clin Path 36:212-219 ( (Sept) ) 1961.
11.
Schatz, I.J., and Hathaway, J.C.:  Heparin Therapy and Thrombin Times ,  JAMA 186:740 ( (Nov 16) ) 1963.Crossref
12.
Engelberg, H.:  Heparin Metabolism: Physiology and Clinical Application , Springfield, Ill: Charles C Thomas, Publisher, 1963, p 106.
13.
Conley, C.L.; Hartmann, R.C.; and Lalley, J.S.:  The Relationship of Heparin Activity to Platelet Concentration ,  Proc Soc Exp Biol Med 69:284-287 ( (Nov) ) 1948.Crossref
×