[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
July 17, 1967

A Rapid Metabolic Screening Test to Evaluate Potential Cadaveric Kidney Donors

Author Affiliations

From the Department of Surgery and the Division of Urology, University of California at Los Angeles School of Medicine, Los Angeles.

JAMA. 1967;201(3):160-164. doi:10.1001/jama.1967.03130030030007

A tetrazolium dye reduction test has been evaluated for use in assessing the suitability of cadaver kidneys for transplantation. The time required for a color change of a small cortical slice was measured. Nine human cadaveric kidney transplants were tested and the results generally paralleled the severity of the acute tubular necrosis present. In a simulated cadaver experiment with canine kidneys subjected to varying periods of ischemia, the tetrazolium test could identify kidneys which would not recover function. Its greatest potential value appears to be in the utilization of kidneys previously thought unsuitable. A favorable test result in a donor kidney which was subjected to 48 hours of severe shock and 36 hours of total anuria which was unresponsive to mannitol, resulted in a successful transplantation to a recipient who otherwise might have been denied a kidney.

Hume, D.M., et al:  Comparative Results of Cadaver and Related Donor Renal Homografts in Man, and Immunologic Implications of the Outcome of Second and Paired Transplants ,  Ann Surg 164:352-397 ( (Sept) ) 1966.Crossref
Straffon, R.A., et al:  Clinical Experience With the Use of 79 Kidneys From Cadavers for Transplantation ,  Surg Gynec Obstet 123:483-492 ( (Sept) ) 1966.
Starzl, T.E., et al:  Chronic Survival After Renal Homotransplantation ,  Ann Surg 162:749-784 ( (Oct) ) 1965.Crossref
 Histocompatability Testing 1965: Report of a Conference and Workshop by the Boerhaave Courses for Post Graduate Medical Education, University of Leiden, Aug 15-21; 1965 , Copenhagen: Munksgaard, 1965.
Terasaki, P.I., et al:  Serotyping For Homotransplantation: V. Evaluation of a Matching Scheme ,  Transplantation 4:688-699 ( (Nov) ) 1966.Crossref
Manax, W.G.; Largiader, F.; and Lillehei, R.C.:  Whole Canine Organ Preservation: Prolongation in Vitro by Hypothermia and Hyperbaria ,  JAMA 196:1121-1124 ( (June 27) ) 1966.Crossref
Ladaga, L.G., et al:  Preservation of Canine Kidneys by Hypothermia and Hyperbaric Oxygen ,  Ann Surg 163:553-558 ( (April) ) 1966.Crossref
Ackermann, J.R.W., and Barnard, C.N.:  Successful Storage of Kidneys ,  Brit J Surg 53:525-532 ( (June) ) 1966.Crossref
Terasaki, P.I.; Martin, D.C.; and Smith, R.B.:  A Rapid Metabolic Test to Screen Cadaver Kidneys for Transplantation ,  Transplantation 5:76-78 ( (Jan) ) 1967.Crossref
Slater, T.F., and Smith, J.F.:  Studies on Succinate-Tetrazolium Reductase Systems: IV. Histochemical Aspects ,  Biochim Biophys Acta 110:81-90 ( (Oct 25) ) 1965.Crossref