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Article
Sept 11, 1967

Estimation of Thyroid Function by Timing the Arterial Sounds

Author Affiliations

From Hahnemann Medical College and Hospital, Philadelphia (Dr. D. Rodbard), University of Tokyo (Dr. Fujita), and City of Hope Medical Center, Duarte, Calif (Dr. S. Rodbard). Dr. D. Rodbard is now at the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.

JAMA. 1967;201(11):884-887. doi:10.1001/jama.1967.03130110110038
Abstract

The timing of the Korotkoff arterial sounds with reference to the electrocardiogram provides an objective index of thyroid function which is precise, accurate, rapid, innocuous, inexpensive, and independent of iodine metabolism. QKd is the interval between the QRS and the onset of Korotkoff sounds at diastolic pressure. The QKd value in 80 euthyroid subjects had a normal range of 186 to 235 msec. Ten patients with hypothyroidism had QKd values ranging from 230 to 320 msec.

References
1.
Graig, F.A., and Smith, J.C.:  Serum Creatine Phosphokinase Activity in Altered Thyroid States ,  J Clin Endocr 25:723-731 ( (June) ) 1965.Crossref
2.
Rivlin, R.S.; Melmon, K.L.: and Sjoerdsma, A.:  An Oral Tyrosine Tolerance Test in Thyrotoxicosis and Myxedema ,  New Eng J Med 272:1143-1148 ( (June) ) 1965.Crossref
3.
Murray, J.F., and Kelley, J.R., Jr.:  The Relation of Thyroidal Hormone Level to Epinephrine Response: A Diagnostic Test for Hyperthyroidism .  Ann Intern Med 51:309-421 ( (Aug) ) 1959.Crossref
4.
Kohler, P.O., and Wynn, D.:  One-Hour Thyroid Uptake of Radioactive Iodine: A Screening Test for Hyperthyroidism ,  Arch Intern Med 116:177-182 ( (Aug) ) 1965.Crossref
5.
Rodbard, S.; Rubinstein, H.M.; and Rosenblum, S.:  Arrival Time and Calibrated Contour of the Pulse Wave, Determined Indirectly From Recordings of Arterial Compression Sounds ,  Amer Heart J 53:205-212 ( (Feb) ) 1957.Crossref
6.
Rodbard, S., and Kramer, R.:  The Timing of the Arterial Sounds in Hypothyroidism ,  Amer J Med Sci 252:404-412 ( (Oct) ) 1966.Crossref
7.
Rodbard, D.; Fujita, T.; and Rodbard S.:  Estimation of Thyroid Function by Timing of the Arterial Sounds , read before the  American Thyroid Association, Chicago, Oct 15, 1966 .
8.
Fujita, T.; Ito, K; and Rodbard, S.:  Korotkoff Sounds in Hyperthyroidism ,  Endocr Jap , to be published.
9.
Rodbard, S., and Mohrherr, R.:  Device for Indirect Registration of the Calibrated Arterial Upstroke in Man ,  Rev Sci Instrum 32:1022-1023 ( (Sept) ) 1961.Crossref
10.
Graettinger, J.S., et al:  A Correlation of Clinical and Hemodynamic Studies in Patients With Hypothyroidism ,  J Clin Invest 37:502-510 ( (Apri) ) 1958.Crossref
11.
Brewster, W.R., Jr., et al:  The Hemodynamic and Metabolic Interrelationships in the Activity of Epinephrine. Non-epinephrine, and the Thyroid Hormones ,  Circulation 13:1-20 ( (Jan) ) 1956.Crossref
12.
Kontos, H.A., et al:  Mechanism of Certain Abnormalities of the Circulation to the Limbs in Thyrotoxicosis ,  J Clin Invest 44: 947-956 ( (June) ) 1965.Crossref
13.
Scheinberg, P., et al:  Correlative Observations on Cerebral Metabolism and Cardiac Output in Myxedema ,  J Clin Invest 29: 1139-1146 ( (Sept) ) 1950.Crossref
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