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Human growth hormone (HGH) levels were measured by a double antibody radioimmunoassay of plasma from women in both the fasting state, and after insulin-induced hypoglycemia. The tests were performed on 26 normal, ambulatory females'at rest, as a control, and also during the third treatment cycle with a combination-type oral contraceptive. It was found that the oral contraceptive elev[ill] the HGH levels. This would appear to be the mec[ill]m by which oral contraceptives alter carbohydrate metabolism.
Spellacy WN, Carlson KL, Schade SL. Human Growth Hormone Levels in Normal Subjects Receiving an Oral Contraceptive. JAMA. 1967;202(6):451–454. doi:10.1001/jama.1967.03130190057006
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