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November 27, 1967

Ocular Side Effects of Chlorpromazine in a Child

Author Affiliations

Los Angeles

JAMA. 1967;202(9):916. doi:10.1001/jama.1967.03130220104034

To the Editor:—  Since 1964, a number of well-documented publications have reported ocular complications after prolonged phenothiazine therapy. These were described in adult patients earlier by Greiner and Berry1 and recently by Gombos and Yarden,2 but not in young children. The following case illustrates the first complication of this nature to be seen at the Children's Psychiatric Outpatient Clinic of the Los Angeles County General Hospital.

Report of a Case:—  In a 10-year-old boy the diagnosis of "borderline childhood psychosis with organic brain deficit" was made at the age of 4 years. At 6 years of age he was seen because of destructive, uncontrollable behavior, manifested by a desire to kill his younger brother and harm himself.He was hospitalized between January 1964 and October 1965 and subsequently remained a day-care patient until December 1966. Following discharge, the patient was accepted to the educationally handicapped class of the

Greiner, A.C., and Berry, K.:  Skin Pigmentation and Corneal and Lens Opacities With Prolonged Chlorpromazine Therapy ,  Canad Med Assoc J 90:663-665 ( (March 14) ) 1964.
Gombos, G.M., and Yarden, P.E.:  Ocular and Cutaneous Side Effects After Prolonged Chlorpromazine Treatment ,  Amer J Psychiat 123:872-874 ( (Jan) ) 1967.
Ayd, F.J., Jr.:  Drug Holidays ,  Med Sci 18:59-62 ( (March) ) 1967.
Johnson, A.W., and Buffaloe, W.J.:  Chlorpromazine Epithelial Keratopathy ,  Arch Ophthal 76:664-667 ( (Nov) ) 1966.Crossref
Barsa, J.A.; Newton, J.C.; and Saunders, J.C.:  Lenticular and Corneal Opacities During Phenothiazine Therapy ,  JAMA 193:10-12 ( (July 5) ) 1965.Crossref
Satanove, A., and McIntosh, J.S.:  Phototoxic Reactions Induced by High Doses of Chlorpromazine and Thioridazine ,  JAMA 200:209-212 ( (April 17) ) 1967.Crossref
Kinross-Wright, J.:  The Current Status of Phenothiazines ,  JAMA 200:461-464 ( (May 8) ) 1967.Crossref