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December 4, 1967

Xylose Absorption and Duodenal Diverticula

Author Affiliations

Winfield, Kan

JAMA. 1967;202(10):992. doi:10.1001/jama.1967.03130230118037

To the Editor:—  Numerous investigators1-4 have reported that the measurement of the urinary excretion of xylose after the oral administration of the sugar is a reliable means of testing the absorption of carbohydrates. Xylose is not metabolized by the body but is excreted unchanged in the urine. We used this test to establish whether patients with duodenal diverticula had demonstrable evidence of malabsorption. Serum carotene levels have also been found useful in screening patients from malabsorption.3Most of the individuals with duodenal diverticula were over 50 years old. None had diverticula of the ileum or jejunum. As we took data on these patients, we became aware that the lowest xylose excretion values were in the oldest patients. Texter3 reports a decrease in xylose excretion after the sixth decade. However, our data were inadequate to allow statistical evaluation of our patient group.

Methods and Materials:—  Food was withheld

Christiansen, P.A.; Kirsner, J.B.; and Ablaza, J.:  D-Xylose and Its Use in the Diagnosis of Malabsorptive States ,  Amer J Med 27:443-453 ( (Sept) ) 1959.Crossref
Butterworth, C.E., Jr., et al:  Studies on the Oral and Parenteral Administration of D (+) Xylose ,  New Eng J Med 261:157-164 ( (July 23) ) 1959.Crossref
Texter, E.C., Jr.; et al:  Laboratory Procedures in the Diagnosis of Malabsorption ,  Med Clin N Amer 48:117-136 ( (Jan) ) 1964.
Fordtran, J.S.; Soergel, K.H.; and Ingelfinger, F.J.:  Intestinal Absorption of D-Xylose in Man ,  New Eng J Med 267:274-279 ( (Aug 9) ) 1962.Crossref
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Bessey, O.A., et al:  The Determination of Vitamin A and Carotene in Small Quanities of Serum ,  J Biol Chem 166:177-188 ( (Nov) ) 1946.