[Skip to Content]
[Skip to Content Landing]
December 18, 1967

Peritoneal Dialysis in Quinine Sulfate Intoxication

Author Affiliations

From the Department of Internal Medicine and the Institute of Industrial Health, University of Michigan, Ann Arbor. LCDR Markham is now at the Submarine Medical Center, Groton, Conn, and Dr. Eckberg is now at the National Institutes of Health, Bethesda, Md.

JAMA. 1967;202(12):1102-1103. doi:10.1001/jama.1967.03130250084021

Early cinchonism developed in an 18-year-old girl after the ingestion of 3.84 gm of quinine sulfate, in an attempt to induce abortion. Initially, the exact dose was unknown and she was treated with peritoneal dialysis. Although dialysis was begun after the peak plasma levels had passed, 415 mg (10.8%) were recovered in the dialysate fluid over the next 16 hours.

Solmann, T.:  A Manual of Pharmacology and Its Application to Therapeutics and Toxicology , ed 8, Philadelphia: W. B. Saunders Co., 1957, pp 696-705.
Kaye, S.:  Handbook of Emergency Toxicology , ed 2, Springfield, Ill.: Charles C Thomas, Publishers, 1961, pp 48-58.
Taggart, J.V., et al:  Studies on the Chemotherapy of Human Malarias: III. The Physiological Disposition and Antimalarial Activity of the Cinchona Alkaloids ,  J Clin Invest 27:80-86 ( (May) ) 1948.Crossref
Hillman, E., and Harpur, E. R.:  Quinine Poisoning ,  New Eng J Med 264:138-139 ( (Jan 19) ) 1961.Crossref
Clark, J.E., and Soricelli, R.R.:  Indication for Dialysis ,  Med Clin N Amer 49:1213-1239 ( (Sept) ) 1965.
Lang, P.A., and Jones, C.C.:  Acute Renal Failure Precipitated by Quinine Sulfate in Early Pregnancy ,  JAMA 188:464-466 ( (May 4) ) 1964.Crossref
Schreiner, G.E.:  The Role of Hemodialysis (Artificial Kidney) in Acute Poisoning ,  Arch Intern Med 102:896-913 ( (Dec) ) 1958.Crossref
Niehuis, L.I.:  Clinical Peritoneal Dialysis ,  Arch Surg 93:643-653 ( (Oct) ) 1966.Crossref