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Article
February 3, 1984

Decreased Spinal Mineral Content in Amenorrheic Women

Author Affiliations

From the Departments of Radiology (Drs Cann and Genant) and Obstetrics, Gynecology, and Reproductive Sciences (Drs Martin and Jaffe), University of California, San Francisco.

JAMA. 1984;251(5):626-629. doi:10.1001/jama.1984.03340290040017
Abstract

Premenopausal amenorrheic women may be at risk for the development of osteoporosis. In hyperprolactinemia, cortical bone mass is decreased and the magnitude of the decrease correlates with the severity of the estrogen deficiency. However, bone loss in women with amenorrhea from other causes has not been assessed. We have studied women with hypothalamic and hyperprolactinemic amenorrhea and premature ovarian failure. Bone mass in the peripheral cortical bone was only slightly decreased from age-matched controls, but spinal trabecular bone was decreased 20% to 30%. Estradiol levels were 20 to 80 pg/mL in these women, not different from normal early follicular levels. The decrease in bone mass in the spine did not correlate with serum estradiol at these levels. The hypothalamic amenorrhea group was made up of athletes in whom the bone mass decrease was an unexpected finding.

(JAMA 1984;251:626-629)

References
1.
Nachtigall LE, Nachtigall RH, Nachtigall RD, et al:  Estrogen replacement therapy: I. A ten-year prospective study in the relationship to osteoporosis .  Obstet Gynecol 1979;53:277-281.
2.
Klibanski A, Neer RM, Beitins IZ, et al:  Decreased bone density in hyperprolactinemic women .  N Engl J Med 1980;303:1511-1514.Crossref
3.
Schlechte JA, Sherman B, Martin R:  Bone density in amenorrheic women with and without hyperprolactinemia .  J Clin Endocrinol Metabol 1983;56:1120-1123.Crossref
4.
Chang RJ, Jaffe RB:  Progesterone effect on gonadotropin release in women pretreated with estradiol .  J Clin Endocrinol Metabol 1978;47:119-125.Crossref
5.
Seron-Ferre M, Monroe SE, Hess D, et al:  Prolactin concentrations in the monkey fetus during the last third of gestation .  Endocrinology 1979;104:1243-1246.Crossref
6.
Cann CE, Genant HK:  Precise measurement of vertebral mineral content by computed tomography .  J Comput Assist Tomogr 1980; 4:493-500.Crossref
7.
Genant HK, Cann CE, Ettinger B, et al:  Determination of bone mineral loss in the axial and appendicular skeleton of oophorectomized women , abstracted.  J Comput Assist Tomogr 1982;6:217-218.Crossref
8.
Cameron JR, Sorenson J:  Measurement of bone mineral in vivo: An improved method .  Science 1963;142:230-232.Crossref
9.
Garn SM:  The earlier gain and the later loss of cortical bone , in Garn SM (ed):  Nutritional Perspective . Springfield, Ill, Charles C Thomas Publisher, 1970, p 146.
10.
Riggs BL, Wahner HW, Dunn WL, et al:  Differential changes in bone mineral density of the appendicular and axial skeleton with aging: Relationship to spinal osteoporosis .  J Clin Invest 1981;67:328-335.Crossref
11.
Arnold JS:  Amount and quality of trabecular bone in osteoporotic vertebral fractures .  Clin Endocrinol 1973;2:221-238.Crossref
12.
Cann CE, Genant HK:  Cross-sectional studies of vertebral mineral using computed tomography , abstracted.  J Comput Assist Tomogr 1982;6:216-217.Crossref
13.
Lindsay R, Hart DM, Aitkin JM, et al:  Long-term prevention of postmenopausal osteoporosis by oestrogen .  Lancet 1976;1:1038-1040.Crossref
14.
Meunier P, Courpron P, Edouard C, et al:  Physiological senile involution and pathological rarefaction of bone .  Clin Endocrinol 1973;2:239-256.Crossref
15.
Genant HK, Cann CE, Ettinger B, et al:  Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy .  Ann Intern Med 1982;97:699-705.Crossref
16.
Cann CE, Genant HK, Ettinger B, et al:  Spinal mineral loss in oophorectomized women: Determination by quantitative computed tomography .  JAMA 1980;244:2056-2059.Crossref
17.
Harris WH, Heaney RP:  Effect of growth hormone on skeletal mass in adult dogs .  Nature 1969;223:403-404.Crossref
18.
Bohnet HG, Dahten HG, Wuttke W, et al:  Hyperprolactinemic anovulatory syndrome .  J Clin Endocrinol Metabol 1976;42:132-143.Crossref
19.
Franks S, Murray MAF, Jequier AM, et al:  Incidence and significance of hyperprolactinemia in women with amenorrhea .  Clin Endocrinol 1975;4:597-607.Crossref
20.
Shangold M, Gatz M, Thysen B:  Serum concentrations of prolactin in female runners . Read before the  Endocrine Society (64th annual meeting), San Francisco, June 1982.
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