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June 15, 1984

Hürthle Cell Tumors of the Thyroid Gland: A Clinicopathologic Review and Long-term Follow-up

Author Affiliations

From the Departments of Internal Medicine (Dr Caplan), Pathology (Dr Abellera), and General Surgery (Dr Kisken), Gundersen Clinic, Ltd; La Crosse (Wis) Lutheran Hospital.

JAMA. 1984;251(23):3114-3117. doi:10.1001/jama.1984.03340470040023

We reviewed the pathology and clinical follow-up of 26 patients with Hürthle cell adenomas and three patients harboring Hürthle cell carcinomas, who were treated at our medical center from 1950 to 1979. Although benign lesions could not be distinguished from malignant tumors by cytologic features alone, other pathologic features allowed differentiation. A total thyroidectomy was performed in only one patient; the remaining patients were treated by less extensive operations. None of the patients with benign adenomas, including those with tumors greater than 2 cm in diameter, experienced recurrent or metastatic disease. The period of observation varied from two to 22 years (mean, 8.5 ±7.7 years). We conclude that lobectomy is a satisfactory operation for removal of benign Hürthle cell tumors, and reserve total or near-total thyroidectomy for cases displaying pathologic evidence of malignancy.

(JAMA 1984;251:3114-3117)

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