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October 26, 1984


JAMA. 1984;252(16):2201-2205. doi:10.1001/jama.1984.03350160069021

... interferons, interleukins, arachidonic acid metabolites, and cell-derived chemotactic factors.

New knowledge about rheumatic diseases has been generated at an ever-increasing pace. Comparison of the first edition of Arthritis and Allied Conditions, edited by Bernard Comroe (1940), with the subsequent nine editions provides ample documentation. A few recent highlights are discussed herein.

Perhaps the most striking recent discovery is the spirochetal etiology of Lyme arthritis, now more properly termed "Lyme disease."1 This syndrome was first detected in Lyme, Conn, because of a close geographic clustering of children with what was thought to be juvenile rheumatoid arthritis. The illness begins in warm weather as a characteristic rash, consisting of an expanding reddened area with central clearing and induration called "erythema chronica migrans." This lesion (stage 1) is sometimes followed weeks to months later by cardiac or neurological symptoms (stage 2) and weeks to years later by arthritis (stage 3). Lyme disease is

Steere AC, Grodzicki RL, Kornblatt AN, et al:  The spirochetal origin of Lyme disease .  N Engl J Med 1983;308:733-740.Crossref
Steere AC, Hutchinson GJ, Rahn DW, et al:  Treatment of the early manifestations of Lyme disease .  Ann Intern Med 1983;99:22-26.Crossref
Smythe HA:  Nonarticular rheumatism and psychogenic musculoskeletal syndromes , in McCarty DJ (ed):  Arthritis and Allied Conditions—A Textbook of Rheumatology , ed 9. Philadelphia, Lea & Febiger, 1979, pp 881-891.
Moldofsky H, Lue F:  Alpha and delta EEG frequencies, pain, and mood in 'fibrositic' patients treated with chlorpromazine and L-tryptophan .  Electroencephalogr Clin Neurophysiol 1980;50:71-80.Crossref
Yunus M, Masi AT, Calabro JJ, et al:  Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls .  Sem Arthritis Rheum 1981;11:151-171.Crossref
Cambell SM, Clark S, Tindall EA, et al:  Clinical characteristics of fibrositis: I. A 'blinded,' controlled study of symptoms and tender points .  Arthritis Rheum 1983;26:817-824.Crossref
Nishikai M, Reichlin M:  Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis: Characterization of the Jo, antibody system .  Arthritis Rheum 1980;23:881-888.Crossref
Gilliam JN, Sontheimer RD:  Distinctive cutaneous subsets in the spectrum of lupus erythematosus .  J Am Acad Dermatol 1981;4:471.Crossref
Scott JS, Maddison PJ, Taylor PV, et al:  Connective tissue disease, antibodies to ribonucleoprotein and congenital heart block .  N Engl J Med 1983;309:209-212.Crossref
Tan EM, Rodnan GP, Garcia I, et al:  Diversity of antinuclear antibodies in progressive systemic sclerosis: Anticentromere antibody and its relationship to CREST syndrome .  Arthritis Rheum 1980;23:617-625.Crossref