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November 16, 1984

Choice of Psychotropic Drugs

Author Affiliations

Tufts University School of Medicine Boston

JAMA. 1984;252(19):2702. doi:10.1001/jama.1984.03350190012010

To the Editor.—  I would like to clarify a statement in my previous letter, in which I described the anxiolytic alprazolam (Xanax) as "exceptional."1 I meant to convey that, unlike conventional antianxiety agents, alprazolam seems to have antidepressant properties.2 Indeed, its use in anxious, depressed patients may be accompanied by neuroendocrine changes suggestive of recovery from depression.3

Pies R:  Choice of psychotropic drugs .  JAMA 1984; 252:765.Crossref
Feighner JP, Aden GC, Fabre LF, et al:  Comparison of alprazolam, imipramine, and placebo in the treatment of depression .  JAMA 1983;249:3057-3064.Crossref
Pies R:  Alprazolam for panic disorder and depression .  Am J Psychiatry 1983;140:640.