[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
December 7, 1984

CIN or Not to Sin

Author Affiliations

Veterans Administration Medical Center Albuquerque

JAMA. 1984;252(21):3012-3013. doi:10.1001/jama.1984.03350210060033

Cervical neoplasia has been extensively studied with respect to its pathological and epidemiologic factors. There is a continuum of disease that ranges from cervical intraepithelial neoplasia (CIN)1 to widespread metastatic disease.

The risk factors for CIN or invasive cancers developing appear to be similar. The epidemiology of cervical neoplasia was first studied by Gagnon,2 who showed that this disease was absent in a population of Canadian nuns. Since this initial study, it is clear that cervical cancer is related to a number of identifiable risk factors, including early sexual activity, multiple pregnancies, multiple sexual partners, early age at first pregnancy or first marriage, promiscuity, and exposure to a "high-risk" male sexual partner. When all of the epidemiologic risk factors are analyzed, one finds that they have in common the degree of sexual activity engaged in by the women with cervical neoplasia or by their sexual partner(s) and that

Richart RT:  Cervical intraepithelial neoplasia .  Pathol Ann 1973;8:301-328.
Gagnon F:  Contributions to study of etiology and prevention of cancer of uterus .  Am J Obstet Gynecol 1950;60:516-522.
Kessler II:  Venereal factors in human cervical cancer: Evidence from marital clusters .  Cancer 1977;39:1912-1919.Crossref
Fenoglio CM, Ferenczy A:  Etiologic factors in cervical neoplasia .  Sem Oncol 1982;9:349-372.
Robboy SJ, Noller KL, O'Brien P, et al:  Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women: Experience of the National Collaborative Diethylstilbestrol Adenosis Project .  JAMA 1984;252:2979-2983.Crossref
Stafl A, Mattingly RF:  Vaginal adenosis—a precancerous lesion?  Am J Obstet Gynecol 1974;120:666-677.
Robboy SJ, Keh PC, Nickerson RJ, et al:  Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol: Examination and follow up of 1,424 females .  Obstet Gynecol 1978;51:528-535.Crossref