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Article
July 6, 1912

THE CONDITIONS FOR THE EFFECTIVE ACTION OF URINARY ANTISEPTICS

JAMA. 1912;LIX(1):38-41. doi:10.1001/jama.1912.04270070040016
Abstract

An accurate knowledge of the exact pharmacologic behavior of the drugs employed is a fundamental requisite of the best type of therapeutics. A considerable number of drugs are given as urinary antiseptics by way of the mouth. The urine is an excellent nutrient medium for microorganisms when once they are established therein; but further than this, its reaction is variable through a considerable range of mild acidity to distinct alkalinity, so that the effect of any chemical compound therein may be modified from time to time by the prevailing reaction of the secretion. The usefulness of hexamethylenamin, sold under a variety of trade names, as a urinary antiseptic is established by the consensus of a wide clinical use. The theory of its action centers in the liberation of formaldehyd from the compound on treatment with acid. The object in giving hexamethylenamin is to administer formaldehyd.

Dr. Jordan1 has reported

References
1.
Jordan, A. R.:  Urinary Antiseptics: An Experimental Investigation ,  Proc. Roy. Soc. Med. , 1911, v, No. (2) .
2.
MacCallum, J. B.: The Mechanism of the Physiologic Action of Cathartics, Univ. California Publications, Physiology, 1904, iii.
3.
Meltzer, S. J., and Auer, J.:  Physiologic and Pharmacologic Studies of Magnesium Salts ,  Am. Jour. Physiol. , 1906, xvii, 313.
4.
Tyrode, M. V.:  The Mode of Action of Some Purgative Salts ,  Arch. internat, de Pharmacodyn. et de Thérap. , 1910, xx, Nos. (3-4) .
5.
 The Journal A. M. A. , (April 13) , 1912, p. 1119.
6.
Lumsden: Bull. 78, Hyg. Lab. U. S. P. H. and M.-H. S., p. 165.
7.
Hinton:  Institution Quarterly , 1912, iii, 18.
8.
Kayser:  Münch. med Wchnschr. , 1909, lvi, 1066.
9.
Howell, Katharine:  Am. Jour. Pub. Health , 1912, ii, 321.Crossref
10.
Flexner, Abraham: Medical Education in Europe, Bull.No. 6, Carnegie Foundation, 576 Fifth Avenue, New York.
11.
American Medical Association Bulletin, May 15, 1908, p. 234
12.
 The Journal A. M. A. , (Aug. 20) , 1910, p. 680.
13.
The resolution, together with other action of the conference, will be found in Pub. Health Rep., June 7, 1912, p. 895
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