Customize your JAMA Network experience by selecting one or more topics from the list below.
The lesion of poliomyelitis confines itself mainly to the cerebrospinal system and produces focal clinical symptoms. This part of the human organism is rather remote from the external surface of the body and very tightly boxed in, as it were, and well protected from external influences. An infection, therefore, must primarily reach these tissues either through the circulatory or through the lymphatic system.
Experimentally, the disease was produced by injecting monkeys with the infected spinal cord and brain intracerebrally, intraperitoneally, by rubbing it into an abraded surface and an unabraded oneof the nasal mucosa, into the nerve-sheath and finally by rubbing it into an abraded surface of the skin. It was further shown that the nasal mucosa contains the virus quite early in the incubation period of the disease—three days after injection of the virus—and that the tonsils, the salivary glands, the retroperitoneal glands and lung tissue are infected as
NEUSTAEDTER M. A CONTRIBUTION TO THE ETIOLOGY OF POLIOMYELITIS. JAMA. 1912;LIX(10):785–788. doi:10.1001/jama.1912.04270090029009
Coronavirus Resource Center
Create a personal account or sign in to: