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January 2, 1967

Bronchial Lavage in Cystic Fibrosis: A Comparison of Agents

Author Affiliations

From the Division of Anesthesiology (Drs. Cezeaux, Telford, and Keats) and the Department of Pediatrics (Dr. Harrison), Baylor University College of Medicine, and the Texas Institute for Rehabilitation and Research, Texas Medical Center, Houston.

JAMA. 1967;199(1):15-18. doi:10.1001/jama.1967.03120010059010

The relative benefits and hazards of bronchial lavage with 10% acetylcysteine (Mucomyst) compared to sodium chloride solution was studied in 14 patients with cystic fibrosis who were treated on 16 occasions. Lavage with acetylcysteine produced a significant increase in arterial carbon dioxide tension (Paco2) and a decrease in arterial oxygen tension (Pao2) immediately after lavage. Lavage with sodium chloride solution produced a decrease in Paco and an increase in `Pao2. Regardless of lavage agent, pulmonary function was impaired for 48 to 72 hours after lavage, and three patients developed pneumonia within three days after lavage. When bronchial lavage was used as one part of a complete therapeutic program, some improvement in pulmonary function could be demonstrated two to six weeks after therapy.

Hacket, R.R., and Reas, H.W.:  A Radical Approach to Therapy for the Pulmonary Complications of Cystic Fibrosis .  Anesthesiology 26:248 ( (March) -April) 1965.Crossref
Ramirez, R.J.; Kieffer, R.F.; and Ball, W.C.:  Bronchopulmonary Lavage in Man ,  Ann Intern Med 63:819-828 ( (Nov) ) 1965.Crossref
Bernstein, I.L., and Ausdenmoore, R.W.:  Iatrogenic Bronchospasm Occurring During Clinical Trials of a New Mucolythic Agent, Acetylcysteine ,  Dis Chest 46:469-473 ( (Oct) ) 1964.Crossref
Thompson, H.T., and Pryor, W.J.:  Bronchial Lavage in the Treatment of Obstructive Lung Diseases .  Lancet 2:8 ( (July 4) ) 1964.Crossref